An Analysis of Behavioral and Genetic Risk Factors for Chemotherapy-Induced Nausea and Vomiting in Japanese Subjects

• Mukoyama Naoki

  Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University

• Yoshimi Akira

  Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University Department of Psychiatry, Graduate School of Medicine, Nagoya University

• Goto Aya

  Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University

• Kotani Haruka

  Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University

• Ishikawa Kazuhiro

  Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University

• Miyazaki Noriko

  Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University

• Miyazaki Masayuki

  Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University

• Yamada Kiyofumi

  Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University

• Kikkawa Fumitaka

  Department of Obstetrics and Genecology, Graduate School of Medicine, Nagoya University

• Hasegawa Yoshinori

  Department of Respiratory Medicine, Graduate School of Medicine, Nagoya University

• Ozaki Norio

  Department of Psychiatry, Graduate School of Medicine, Nagoya University

• Noda Yukihiro

  Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University Department of Psychiatry, Graduate School of Medicine, Nagoya University Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University

Abstract

There are individual differences in the frequency of chemotherapy-induced nausea and vomiting (CINV) in cancer patients. We investigated the individual variability in susceptibility to CINV with focus on both behavioral factors and genetic factors in Japanese cancer patients. We performed a prospective study to investigate the association between patient attributes (backgrounds and habits as well as gene polymorphisms) and anorexia, nausea, or vomiting in 55 Japanese cancer patients undergoing chemotherapy at Nagoya University Hospital. We found that gender (female), use of non-steroidal anti-inflammatory drugs, susceptibility to motion sickness, and anxiety were associated with the frequency of CINV. Gene polymorphisms of rs1076560 (dopamine D₂ receptor gene), rs6766410 (serotonin 5-HT_3C receptor gene) and rs4680 (catechol-O-methyltransferase gene) were also associated. Our data suggest that these attributes may thus be risk factors for CINV. Our results provide novel information that can be used to predict the incidence of CINV in Japanese patients undergoing chemotherapy; this can help provide a substantial improvement in supportive care for patients with different types of cancer.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 39 (11), 1852-1858, 2016

  The Pharmaceutical Society of Japan

Keywords

• chemotherapy
• anorexia
• nausea
• vomiting
• gene polymorphism
• risk factor

Details

• CRID: 1390001204634334976
• NII Article ID: 130005268684
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.b16-00440
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 027685505
• PubMed: 27803457
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027685505
• Web Site: https://www.jstage.jst.go.jp/article/bpb/39/11/39_b16-00440/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017175808
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed