Synthesis and Antimicrobial Activity of Nitrobenzyl-oxy-phenol Derivatives

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  • Mohamed Malik Suliman
    Department of Pharmaceutics, Faculty of Pharmacy University of Khartoum
  • Maki Toshihide
    Graduate School of Biomedical Sciences, School of Pharmaceutical Sciences, Nagasaki University
  • Shah Mohammad Monir
    Kenya Research Station, Institute of Tropical Medicine, Nagasaki University
  • Ichinose Yoshio
    Kenya Research Station, Institute of Tropical Medicine, Nagasaki University

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<p>Two hydroquinone derivatives were prepared and their antimicrobial activity evaluated. Their minimum inhibitory concentrations (MICs) were determined using a broth dilution method. Gentamycin and ciprofloxacin were used as reference antibiotics. The antimicrobial activity of 4-(benzyloxy)phenol (monobenzone) was also evaluated based on its structural similarity to the new compounds; activity was comparable to that of 3,5-dimethyl-4-((4-nitrobenzyl)oxy)phenol (4a). 2,3,5-Trimethyl-4-((4-nitrobenzyl)oxy)phenol (4b) exhibited the best antibacterial activity against both clinical isolates and type strain of Moraxella catarrhalis (M. catarrhalis), with a MIC value of 11 µM, comparable to ciprofloxacin 9 µM.</p>

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