Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis
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- Mannoji Hiroshi
- Division of Cardiology, Cardiovascular and Aortic Center, Saiseikai Fukuoka General Hospital, Japan
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- Hayashi Fumie
- Division of Neurology, Saiseikai Fukuoka General Hospital, Japan
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- Kubota Toru
- Division of Cardiology, Cardiovascular and Aortic Center, Saiseikai Fukuoka General Hospital, Japan
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- Ikeda Yoshihiko
- Pathology Department, NCVC Biobank, National Cerebral and Cardiovascular Center, Japan
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- Ishibashi-Ueda Hatsue
- Pathology Department, NCVC Biobank, National Cerebral and Cardiovascular Center, Japan
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- Kato Seiya
- Division of Pathology, Saiseikai Fukuoka General Hospital, Japan
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- Tahara Nobuhiro
- Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Japan
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- Fukutomi Takayoshi
- Fukutomi Internal Medicine Clinic, Japan
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- Yamada Takeshi
- Division of Neurology, Saiseikai Fukuoka General Hospital, Japan
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- Okabe Masanori
- Division of Cardiology, Cardiovascular and Aortic Center, Saiseikai Fukuoka General Hospital, Japan
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- Yamamoto Yusuke
- Division of Cardiology, Cardiovascular and Aortic Center, Saiseikai Fukuoka General Hospital, Japan
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Abstract
<p>A 49-year-old female was referred to our hospital due to high serum creatine kinase (CK) (2,605 IU/L) and serum cardiac troponin T (cTnT) (0.342 ng/mL) levels. She had no other complaints and further examinations suggested no signs of cardiac disease. Additionally, the serum cardiac troponin I (cTnI) levels were normal. She reported having gradually felt difficulty in walking upstairs. A biopsy indicated skeletal muscle sarcoidosis with positive staining for cTnT. Steroid therapy immediately resolved her muscular symptoms with a normalization of the serum CK levels. Since the serum levels of cTnI were normal, the concomitant measurement of cTnT/cTnI might be useful to diagnose skeletal muscular disease biochemically in such cases. </p>
Journal
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- Internal Medicine
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Internal Medicine 55 (21), 3215-3217, 2016
The Japanese Society of Internal Medicine