Design of Tetra-arm PEG-crosslinked Thermoresponsive Hydrogel for 3D Cell Culture

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  • AKIMOTO Aya Mizutani
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo
  • HASUIKE Erika
    Department of Pharmacy, Keio University
  • TADA Hiroto
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo
  • NAGASE Kenichi
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University
  • OKANO Teruo
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University
  • KANAZAWA Hideko
    Department of Pharmacy, Keio University
  • YOSHIDA Ryo
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo

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抄録

We synthesized poly(N-isopropylacrylamide) gel containing cell-adhesive peptides, RGDS pendants, and crosslinked by a hydrophilic polymer. Since gelation occurs by simply mixing the polymers, cells can be simultaneously encapsulated inside the gel during gelation. This gel has roughly a 15% volume change between 25 and 37°C, and is transparent at both temperatures. Moreover, adhesion of encapsulated C2C12 cells to the gel could be observed. This thermoresponsive gel would be potentially useful as a cell culture material that can control cell fate by changing mechanical properties of the cell’s external environment.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 32 (11), 1203-1205, 2016

    社団法人 日本分析化学会

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