Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings
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- Hatano Masako
- Department of Endocrinology and Diabetes, Saitama Medical University, Japan
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- Takenaka Yasuhiro
- Department of Endocrinology and Diabetes, Saitama Medical University, Japan
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- Inoue Ikuo
- Department of Endocrinology and Diabetes, Saitama Medical University, Japan
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- Homma Keiko
- Central Clinical Laboratories, Keio University Hospital, Japan
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- Hasegawa Tomonobu
- Department of Pediatrics, Keio University School of Medicine, Japan
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- Sasano Hisanobu
- Department of Pathology, Tohoku University Graduate School of Medicine, Japan
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- Awata Takuya
- Department of Endocrinology and Diabetes, Saitama Medical University, Japan
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- Katayama Shigehiro
- Department of Endocrinology and Diabetes, Saitama Medical University, Japan
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抄録
<p>We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 55 (22), 3301-3307, 2016
一般社団法人 日本内科学会
