Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings

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Author(s)

    • Hatano Masako
    • Department of Endocrinology and Diabetes, Saitama Medical University, Japan
    • Takenaka Yasuhiro
    • Department of Endocrinology and Diabetes, Saitama Medical University, Japan
    • Inoue Ikuo
    • Department of Endocrinology and Diabetes, Saitama Medical University, Japan
    • Homma Keiko
    • Central Clinical Laboratories, Keio University Hospital, Japan
    • Sasano Hisanobu
    • Department of Pathology, Tohoku University Graduate School of Medicine, Japan
    • Awata Takuya
    • Department of Endocrinology and Diabetes, Saitama Medical University, Japan

Abstract

<p>We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution. </p>

Journal

  • Internal Medicine

    Internal Medicine 55(22), 3301-3307, 2016

    The Japanese Society of Internal Medicine

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