Current Topics of Implantation of BCNU Wafers for the Treatment of Malignant Glioma

• Matsuda Ryosuke

  Department of Neurosurgery, Nara Medical University

• Nakamura Mitsutoshi

  Department of Neurosurgery, Nara Medical University

• Tanaka Yoshitaka

  Department of Neurosurgery, Nara Medical University

• Omoto Koji

  Department of Neurosurgery, Nara Medical University

• Nishimura Fumihiko

  Department of Neurosurgery, Nara Medical University

• Nakagawa Ichiro

  Department of Neurosurgery, Nara Medical University

• Motoyama Yasushi

  Department of Neurosurgery, Nara Medical University

• Park Young-Su

  Department of Neurosurgery, Nara Medical University

• Nakase Hiroyuki

  Department of Neurosurgery, Nara Medical University

Bibliographic Information

Other Title

• BCNU waferカレントトピックス

Abstract

  1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) is an anti-cancer drug that directly attacks residual tumors without systemic toxicity. BCNU wafers were formally approved in 2013 for use in Japan and have already been used in more than 3,000 cases. BCNU wafers act as an anti-tumor agent for malignant glioma in order to suppress tumor regrowth from surgery to adjuvant chemoradiotherapy. Previous reports have demonstrated that complete resection of malignant glioma leads to a significant improvement in patient survival. Besides this, very little is known with regards to improving survival for these patients. For treatment with BCNU wafers, due care must be taken to avoid complications, such as surgical site infection, brain edema, and epilepsy. Because little is known about the potential effects of BCNU wafers in patients treated with standard chemoradiotherapy, it is now necessary to carry out further investigations in larger randomized controlled clinical trials.

Journal

• Japanese Journal of Neurosurgery

  Japanese Journal of Neurosurgery 25 (11), 889-894, 2016

  The Japanese Congress of Neurological Surgeons

Keywords

• BCN wafer
• malignant glioma
• glioblastoma
• chemotherapy

Details

• CRID: 1390001204407139584
• NII Article ID: 130005284632
• DOI: 10.7887/jcns.25.889
• ISSN: 21873100
• ISSN: 0917950X
• Web Site: https://www.jstage.jst.go.jp/article/jcns/25/11/25_889/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017080070
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed