Focal Reduction in Cardiac ¹²³I-Metaiodobenzylguanidine Uptake in Patients With Anderson-Fabry Disease

• Yamamoto Saori

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Suzuki Hideaki

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Sugimura Koichiro

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Tatebe Shunsuke

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Aoki Tatsuo

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Miura Masanobu

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Yaoita Nobuhiro

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Sato Haruka

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Kozu Katuya

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Ota Hideki

  Department of Radiology, Tohoku University Graduate School of Medicine

• Takanami Kentaro

  Department of Radiology, Tohoku University Graduate School of Medicine

• Takase Kei

  Department of Radiology, Tohoku University Graduate School of Medicine

• Shimokawa Hiroaki

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

Abstract

Background:It remains to be elucidated whether cardiac sympathetic nervous activity is impaired in patients with Anderson-Fabry disease (AFD). Methods and Results:We performed ¹²³I-meta-iodobenzylguanidine (MIBG) scintigraphy and gadolinium-enhanced cardiovascular magnetic resonance (CMR) in 5 AFD patients. MIBG uptake in the inferolateral wall, where wall thinning and delayed enhancement were noted on CMR, was significantly lower compared with the anteroseptal wall. The localized reduction in MIBG uptake was also noted in 2 patients with no obvious abnormal findings on CMR. Conclusions:Cardiac sympathetic nervous activity is impaired in AFD before development of structural myocardial abnormalities. (Circ J 2016; 80: 2550–2551)

Journal

• Circulation Journal

  Circulation Journal 80 (12), 2550-2551, 2016

  The Japanese Circulation Society

Keywords

• Anderson-Fabry disease
• Cardiomyopathy
• Cardiovascular magnetic resonance
• MIBG scintigraphy

Details

• CRID: 1390001205107672064
• NII Article ID: 130005285000
• DOI: 10.1253/circj.cj-16-0690
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 27784854
• Web Site: https://www.jstage.jst.go.jp/article/circj/80/12/80_CJ-16-0690/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017211363
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed