Successful alectinib treatment for a mechanically ventilated patient with <i>ALK</i>-positive non-small cell lung cancer

• Watanabe Yasutaka

  Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center

• Koyama Nobuyuki

  Department of Clinical Oncology, Tokyo Medical University Hachioji Medical Center

• Iwai Yuki

  Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center

• Kawamura Rumi

  Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center

• Miwa Chihiro

  Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center

• Nagai Yoshiaki

  Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center

• Hagiwara Koichi

  Department of Pulmonary Medicine, Jichi Medical University

• Koyama Shinichiro

  Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center

抄録

We report a 38-year-old man with poor performance status (PS) who was diagnosed as stage IV non-small cell lung cancer (NSCLC) harboring the echinoderm microtubule-associated protein like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene. Crizotinib, an ALK inhibitor, was administered after a temporary effect of combination cytotoxic chemotherapy. Chest computed tomography showed air space consolidations and diffuse ground glass opacities in the both lungs after 5 days of treatment with crizotinib, and the patient required mechanical ventilation due to respiratory deterioration. For tumor progression, crizotinib was switched to alectinib, the other ALK inhibitor, along with short-term corticosteroid therapy for the possibility of crizotinib-induced pneumonitis. After alectinib administration through a nasogastric tube, tumors regressed with weaning from mechanical ventilation. Safe and successful administration of alectinib through a nasogastric tube may be a therapeutic option for the ALK-positive NSCLC patient with poor PS who fails to take oral medications.

収録刊行物

• Ａｎｎａｌｓ　ｏｆ　Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ　ａｎｄ　Ｔｈｅｒａｐｙ

  Ａｎｎａｌｓ　ｏｆ　Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ　ａｎｄ　Ｔｈｅｒａｐｙ 24 (2), 47-51, 2016

  日本癌病態治療研究会

キーワード

• Lung adenocarcinoma
• <i>EML4-ALK</i> fusion gene
• mechanical ventilation
• nasogastric tube
• alectinib

詳細情報

• CRID: 1390001205188940800
• NII論文ID: 130005285070
• DOI: 10.4993/acrt.24.47
• ISSN: 18805469
• ISSN: 13446835
• Web Site: https://www.jstage.jst.go.jp/article/acrt/24/2/24_47/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018065493
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可