左心室の電気生理・力学統合シミュレーション：興奮伝播様式の違いが収縮動態に与える影響

• 重 文将

  大阪大学大学院　基礎工学研究科

• 稲田 慎

  国立循環器病研究センター

• 伊井 仁志

  大阪大学大学院　基礎工学研究科

• 中沢 一雄

  国立循環器病研究センター

• 和田 成生

  大阪大学大学院　基礎工学研究科

書誌事項

タイトル別名

• Mechano-electric coupling simulation of left ventricle: effect of excitation propagation pattern on contractile behavior

抄録

The left ventricle (LV) plays an important role in pumping blood throughout the body. The LV motion is attributed to an electrophysiological mechanism, i.e. cardiac conduction system and excitation propagation, and mechanical mechanisms, i.e. contraction of the cardiac muscle fibers. In a sinus rhythm, the excitation propagates through the LV due to the electrophysiological stimulus of the heart muscle cells with a constant rhythm. However, in an arrhythmia, the stimulus rhythm becomes inconstant, and some arrhythmia with a severe abnormality results in a reduction of cardiac function. So far, although some computational studies considering the electrophysiological change during arrhythmia have been done, little is known about the effect of coupling mechanism between electrophysiological dynamics and the entire LV kinematic behavior. In this study, an electrophysiological-mechanical integrated LV model is developed, and the effects of the excitation propagations in both the normal and arrhythmia conditions on the LV kinematics are investigated.

収録刊行物

• 生体医工学

  生体医工学 54Annual (26AM-Abstract), S63-S63, 2016

  公益社団法人 日本生体医工学会

詳細情報

• CRID: 1390001205267389056
• NII論文ID: 130005285174
• DOI: 10.11239/jsmbe.54annual.s63
• ISSN: 18814379
• ISSN: 1347443X
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可