Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse
-
- Kimura Eiki
- Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba
-
- Kubo Ken-ichiro
- Department of Anatomy, Keio University School of Medicine
-
- Endo Toshihiro
- Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo
-
- Nakajima Kazunori
- Department of Anatomy, Keio University School of Medicine
-
- Kakeyama Masaki
- Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo Laboratory for Systems Neuroscience and Preventive Medicine, Faculty of Human Sciences, Waseda University
-
- Tohyama Chiharu
- Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba
この論文をさがす
抄録
<p>The aryl hydrocarbon receptor (AhR) avidly binds dioxin, a ubiquitous environmental contaminant. Disruption of downstream AhR signaling has been reported to alter neuronal development, and rodent offspring exposed to dioxin during gestation and lactation showed abnormalities in learning and memory, emotion, and social behavior. However, the mechanism behind the disrupted AhR signaling and developmental neurotoxicity induced by xenobiotic ligands remains elusive. Therefore, we studied how excessive AhR activation affects neuronal migration in the hippocampal CA1 region of the developing mouse brain. We transfected constitutively active (CA)-AhR, AhR, or control vector plasmids into neurons via in utero electroporation on gestational day 14 and analyzed neuronal positioning in the hippocampal CA1 region of offspring on postnatal day 14. CA-AhR transfection affected neuronal positioning, whereas no change was observed in AhR-transfected or control hippocampus. These results suggest that constitutively activated AhR signaling disrupts neuronal migration during hippocampal development. Further studies are needed to investigate whether such developmental disruption in the hippocampus leads to the abnormal cognition and behavior of rodent offspring upon maternal exposure to AhR xenobiotic ligands.</p>
収録刊行物
-
- The Journal of Toxicological Sciences
-
The Journal of Toxicological Sciences 42 (1), 25-30, 2017
一般社団法人 日本毒性学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679882825472
-
- NII論文ID
- 130005286645
-
- NII書誌ID
- AN00002808
-
- ISSN
- 18803989
- 03881350
-
- NDL書誌ID
- 027966265
-
- PubMed
- 28070106
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可