Phenotype of asthma related with high serum periostin levels

• Matsusaka Masako

  Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine

• Kabata Hiroki

  Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine Kawasaki Municipal Hospital

• Fukunaga Koichi

  Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine

• Suzuki Yusuke

  Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine

• Masaki Katsunori

  Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine

• Mochimaru Takao

  Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine

• Sakamaki Fumio

  Division of Pulmonary Medicine, Department of Medicine, Tokai University Hachioji Hospital Department of Medicine, Tokyo Saiseikai Central Hospital

• Oyamada Yoshitaka

  Department of Medicine, National Tokyo Medical Center

• Inoue Takashi

  Department of Medicine, Sanokousei General Hospital

• Oguma Tsuyoshi

  Kawasaki Municipal Hospital Division of Pulmonary Medicine, Department of Medicine, Tokai University, School of Medicine

• Sayama Koichi

  Kawasaki Municipal Hospital

• Koh Hidefumi

  Department of Medicine, Saiseikai Utsunomiya Hospital Department of Medicine, Tachikawa Kyosai Hospital

• Nakamura Morio

  Department of Medicine, Tokyo Saiseikai Central Hospital Department of Medicine, Eiju General Hospital

• Umeda Akira

  Department of Medicine, Shioya Hospital, International University of Health and Welfare

• Ono Junya

  Shino-Test Corporation

• Ohta Shoichiro

  Department of Laboratory Medicine, Saga Medical School

• Izuhara Kenji

  Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School

• Asano Koichiro

  Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine Division of Pulmonary Medicine, Department of Medicine, Tokai University, School of Medicine

• Betsuyaku Tomoko

  Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine

Abstract

Background: Asthma is a heterogeneous disease composed of various phenotypes. Periostin, a molecule inducible with interleukin (IL)-4 or IL-13 in bronchial epithelial cells, is a biomarker of “TH2-high” asthma. The objective of this study is to examine whether the serum periostin concentrations are correlated with the severity, specific phenotype(s), or comorbidity of asthma.<br> Methods: Serum concentrations of periostin were measured in 190 Japanese asthmatic patients and 11 healthy controls. The protocol was registered under UMIN 000002980 in the clinical trial registry.<br> Results: The serum concentrations of periostin were significantly higher (P = 0.014) in asthmatics [70.0 (54.0-93.5) ng/ml] than in healthy subjects [57.0 (39.0-63.0) ng/ml], though we found no correlation between serum periostin concentrations and treatment steps required to control asthma. To characterize “high-periostin” phenotype(s), the patients with asthma were divided among tertiles based on the serum concentrations of periostin. The high-periostin group was older at onset of asthma (P = 0.04), had a higher prevalence of aspirin intolerance (P = 0.04) or concomitant nasal disorders (P = 0.03-0.001), higher peripheral eosinophil counts (P < 0.001), and lower pulmonary function (P = 0.02-0.07). The serum concentrations of periostin were particularly high in asthmatic patients complicated by chronic rhinosinusitis with nasal polyps and olfactory dysfunction. In contrast, neither atopic status, control status of asthma, nor quality of life were related with the “high-periostin” phenotype.<br> Conclusion: Elevated periostin concentrations in serum were correlated with a specific phenotype of eosinophilic asthma, late-onset and often complicated by obstructive pulmonary dysfunction and nasal disorders.

Journal

• Allergology International

  Allergology International 64 (2), 175-180, 2015

  Japanese Society of Allergology

Keywords

• Chronic rhinosinusitis; Eosinophils; Nasal polyp; Olfactory dysfunction; T_H2-high asthma

Details

• CRID: 1390001204632963456
• NII Article ID: 130005290305
• DOI: 10.1016/j.alit.2014.07.003
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893014000069?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893014000069?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2016045337
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed