書誌事項
- タイトル別名
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- Structural Basis for Molecular Interactions in DNA Damage Tolerance
- DNA ニ キズ ガ アッテモ フクセイ オ ツズケル タメ ノ ブンシ メカニズム
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抄録
<p>DNA damage tolerance (DTT) is a cell function to avoid replication arrest by DNA damage during DNA replication. DTT includes two pathways, translesion DNA synthesis (TLS) and template-switched DNA synthesis (TS), regulated by various molecular interactions. TLS is transient DNA synthesis using a damaged template by error-prone DNA polymerases specialized for DNA damage (TLS polymerases). TS, in which one newly synthesized strand is utilized as an undamaged template for replication by replicative polymerases, is error-free process. This review article describes recent progress in structural studies of proteins involved in TLS and TS.</p>
収録刊行物
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- 生物物理
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生物物理 57 (1), 015-019, 2017
一般社団法人 日本生物物理学会
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詳細情報
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- CRID
- 1390282681511531520
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- NII論文ID
- 130005296473
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- NII書誌ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL書誌ID
- 028180703
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可