A New Pain Regulatory System <i>via</i> the Brain Long Chain Fatty Acid Receptor GPR40/FFA1 Signal

• Nakamoto Kazuo

  Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University

Bibliographic Information

Other Title

• 脳内長鎖脂肪酸受容体GPR40/FFA1シグナルを介した新規疼痛制御機構
• ノウナイ チョウサ シボウサン ジュヨウタイ GPR40/FFA1 シグナル オ カイシタ シンキ トウツウ セイギョ キコウ

Abstract

 An increasingly large number of pharmacological and physiological works on fatty acids have shown that the functional properties of fatty acids are regulated by the amount of individual fatty acid intake and the distribution of fatty acids among organs. Recently, it has been determined that G-protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFA1) is activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). GPR40/FFA1 is mainly expressed in the β cell of the pancreas, spinal cord and brain. It is reported that this receptor has a functional role in controlling blood glucose levels via the modulation of insulin secretion. However, its physiological function in the brain remains unknown. Our previous studies have shown that GPR40/FFA1 is expressed in pro-opiomelanocortin (POMC)-positive neurons of the arcuate nucleus, serotonergic neurons in the nucleus raphe magnus, and in noradrenergic neurons in the locus coeruleus. Furthermore, the intracerebroventricular injection of DHA or GW9508, which is a selective GPR40/FFA1 agonist, attenuates formalin-induced inflammatory pain behavior through increasing β-endorphin release in the hypothalamus. It also suppresses complete Freund's adjuvant-induced mechanical allodynia and thermal hyperalgesia. Our findings suggest that brain free long-chain fatty acids-GPR40/FFA1 signaling might have an important role in the modulation of endogenous pain control systems. In this review, I discuss the current status and our recent study regarding a new pain regulatory system via the brain long chain fatty acid receptor GPR40/FFA1 signal.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 137 (2), 199-204, 2017-02-01

  The Pharmaceutical Society of Japan

Keywords

• G-protein-coupled receptor 40/free fatty acid receptor 1
• pain
• antinociception
• polyunsaturated fatty acid
• <i>n</i>-3 fatty acid

Details

• CRID: 1390282681106230272
• NII Article ID: 130005305868
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.16-00208
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 027919884
• PubMed: 28154332
• Web Site: http://id.ndl.go.jp/bib/027919884
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027919884
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/137/2/137_16-00208/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed