微細粒子による免疫系の活性化とアレルギー性炎症  [in Japanese] Particulates Induce Type-2 Immune Responses  [in Japanese]

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Author(s)

    • 黒田 悦史 KURODA Etsushi
    • 大阪大学免疫学フロンティア研究センターワクチン学研究室 Laboratory of Vaccine Science, WPI Immunology Frontier Research Center (IFReC), Osaka University
    • 石井 健 ISHII Ken J.
    • 医薬基盤・健康・栄養研究所創薬デザイン研究センターワクチンデザインプロジェクト|医薬基盤・健康・栄養研究所アジュバント開発プロジェクト Laboratory of Vaccine Design, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition|Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Health and Nutrition

Abstract

<p>Particulates are considered to be one of the causative factors for allergic asthma and rhinitis in developed countries. Indeed, particulates and crystals are reported to activate type-2 immunity, which is associated with allergic responses. Thus far, many studies have been carried out to determine how particulates trigger immune responses; however, the detailed mechanisms by which immune responses are triggered are still unknown. One important clue is that particulates have an adjuvant activity and boost immune responses toward type-2 responses. Most adjuvants are considered to activate innate immunity, and then activated innate immune cells stimulate adaptive immunity, which involves T cells and B cells. That is why many scientists believe that particulate adjuvants directly stimulate innate cells through unique sensor proteins such as pattern-recognition receptors. In this review, we will introduce the proposed mechanisms of particulate-induced immune activation from the viewpoint of the activation of innate immune responses and related receptors and sensors.</p>

Journal

  • Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 72(1), 27-31, 2017

    The Japanese Society for Hygiene

Codes

  • NII Article ID (NAID)
    130005306030
  • Text Lang
    JPN
  • ISSN
    0021-5082
  • Data Source
    J-STAGE 
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