A New System for Three-dimensional Clinostat Synchronized X-irradiation with a High-speed Shutter for Space Radiation Research

• Ikeda Hiroko

  Gunma University Heavy Ion Medical Center

• Souda Hikaru

  Gunma University Heavy Ion Medical Center

• Puspitasari Anggraeini

  Gunma University Initiative for Advanced Research

• Held Kathryn D.

  Gunma University Initiative for Advanced Research Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School

• Hidema Jun

  Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University

• Nikawa Takeshi

  Department of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Graduate School

• Yoshida Yukari

  Gunma University Heavy Ion Medical Center

• Kanai Tatsuaki

  Gunma University Heavy Ion Medical Center

• Takahashi Akihisa

  Gunma University Heavy Ion Medical Center

抄録

Considering further human activity in space, it is necessary to study the biological effects of combined microgravity and space radiation; however, many aspects of these combined effects remain unclear. In the field of space biology, it is difficult to investigate relative biological effectiveness (RBE) and combined effects because the ability to conduct and replicate space experiments is restricted. Therefore, a new three-dimensional (3D) clinostat synchronized X-irradiation system with a high-speed shutter was fabricated following the development of a heavy-ion irradiation system. This study showed that the system could simultaneously irradiate rotating samples using the 3D clinostat, with the samples in a horizontal position. The samples were completely irradiated because of the flatness and symmetry of the irradiation fields. Doses were virtually identical under both standing and rotation conditions, with the difference being <1% under the assumption of X-irradiation at a dose of 1 Gy. Our new device could accurately synchronize X-irradiation and simulated microgravity at the ground level. The device is expected to greatly contribute to space radiation research as a valuable platform for studies concerning RBE and the combined effects of radiation under microgravity.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ　ｉｎ　Ｓｐａｃｅ

  Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ　ｉｎ　Ｓｐａｃｅ 30 (0), 8-16, 2016

  日本宇宙生物科学会

キーワード

• General Medicine

詳細情報

• CRID: 1390282679407437056
• NII論文ID: 130005306533
• DOI: 10.2187/bss.30.8
• ISSN: 1349967X
• ISSN: 09149201
• Web Site: https://www.jstage.jst.go.jp/article/bss/30/0/30_8/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018049520
• 本文言語コード: ja
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