Conversion of Menaquinone-4 in Animal Organs and its Functions
-
- SHIRAKAWA Hitoshi
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
-
- KATSURAI Tomoko
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
-
- KOMAI Michio
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
Bibliographic Information
- Other Title
-
- ビタミンKの生体内変換と生成したメナキノン-4の機能
- ビタミン K ノ セイタイナイ ヘンカン ト セイセイ シタ メナキノン-4 ノ キノウ
Search this article
Abstract
<p>Vitamin K is an essential factor for posttranslational modification (γ-glutamylcarboxylation) of vitamin K-dependent proteins including blood coagulation factors and bone matrix proteins. However, there are many reports regarding novel functions of vitamin K; inhibition of cell proliferation and induction of differentiation in tumor cells, and activation of nuclear receptor SXR/PXR. After ingestion from foods, vitamin K is converted to menaquinone-4, one of vitamin K2, which has geranylgeranyl moiety at 3 position of 2-methylnaphthoquinone, in various organs in human and rodent. UbiA prenyltransferase domain containing 1, UBIAD1, was identified as one of crucial enzyme for this conversion, but entire conversion process has still not elucidated completely. In this review, we described recent knowledge of menaquinone-4 conversion, novel functions of vitamin K, specially menaquinone-4, and discussed physiological meaning of menaquinone-4 conversion in tissues.</p>
Journal
-
- Oleoscience
-
Oleoscience 14 (12), 547-553, 2014
Japan Oil Chemists' Society
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679460123136
-
- NII Article ID
- 130005308199
-
- NII Book ID
- AA11503417
-
- ISSN
- 21873461
- 13458949
-
- NDL BIB ID
- 025936963
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed