Complexes of <i>myo</i>-Inositol-Hexakisphosphate (IP6) with Zinc or Lanthanum for the Decorporation of Radiocesium

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Abstract

<p>Radioactive nuclides leak into the surrounding environment after nuclear power plant disasters, such as the Chernobyl accident and the Fukushima Daiichi Nuclear Power Plant disaster. Cesium-137 (<sup>137</sup>Cs) (<i>t</i><sub>1/2</sub>=30.1 year), a water-soluble radionuclide with a long physical half-life, contaminates aquatic ecosystems and food products. In humans, <sup>137</sup>Cs concentrates in muscle tissue and has a long biological half-life, indicating it may be harmful. <i>myo</i>-Inositol-hexakisphosphate (IP6) is a compound found in grain, beans, and oil seeds. IP6 has the ability to form insoluble complexes with metals, including lanthanum (La) and zinc (Zn). We hypothesized that La-IP6 and Zn-IP6 may promote the elimination of <sup>137</sup>Cs from the body through the adsorption of La-IP6 and Zn-IP6 to <sup>137</sup>Cs in the gastrointestinal tract. Therefore, in this study, we evaluated the adsorptive capacity of La-IP6 and Zn-IP6 complexes with <sup>137</sup>Cs <i>in vitro</i> and <i>in vivo</i>. La-IP6 and Zn-IP6 complexes were stable in acidic solution (pH 1.2) at 37°C. <i>In vitro</i> binding assays indicated that La-IP6 and Zn-IP6 complexes adsorbed <sup>137</sup>Cs, with the adsorption capacity of Zn-IP6 to <sup>137</sup>Cs greater than that of La-IP6. To evaluate the usefulness of La-IP6 and Zn-IP6 <i>in vivo</i>, La-IP6 or Zn-IP6 was administrated to mice after intravenous injection of <sup>137</sup>Cs. However, the biodistribution of <sup>137</sup>Cs in the La-IP6 treated group and the Zn-IP6 treated group was nearly identical to the non-treated control group, indicating that La-IP6 and Zn-IP6 were not effective at promoting the elimination of <sup>137</sup>Cs <i>in vivo</i>.</p>

Journal

  • Chemical and Pharmaceutical Bulletin

    Chemical and Pharmaceutical Bulletin 65(3), 261-267, 2017

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130005397367
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • ISSN
    0009-2363
  • NDL Article ID
    028005831
  • NDL Call No.
    Z53-D167
  • Data Source
    NDL  J-STAGE 
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