Complexes of <i>myo</i>-Inositol-Hexakisphosphate (IP6) with Zinc or Lanthanum for the Decorporation of Radiocesium

• Ogawa Kazuma

  Graduate School of Medical Sciences, Kanazawa University Institute for Frontier Science Initiative, Kanazawa University

• Aoki Miho

  Graduate School of Medical Sciences, Kanazawa University

• Fukuda Tadahisa

  Graduate School of Medical Sciences, Kanazawa University

• Kadono Sumi

  Graduate School of Medical Sciences, Kanazawa University

• Kiwada Tatsuto

  Graduate School of Medical Sciences, Kanazawa University

• Odani Akira

  Graduate School of Medical Sciences, Kanazawa University

Bibliographic Information

Other Title

• Complexes of myo-Inositol-Hexakisphosphate (IP6) with Zinc or Lanthanum for the Decorporation of Radiocesium

Abstract

Radioactive nuclides leak into the surrounding environment after nuclear power plant disasters, such as the Chernobyl accident and the Fukushima Daiichi Nuclear Power Plant disaster. Cesium-137 (¹³⁷Cs) (t_1/2=30.1 year), a water-soluble radionuclide with a long physical half-life, contaminates aquatic ecosystems and food products. In humans, ¹³⁷Cs concentrates in muscle tissue and has a long biological half-life, indicating it may be harmful. myo-Inositol-hexakisphosphate (IP6) is a compound found in grain, beans, and oil seeds. IP6 has the ability to form insoluble complexes with metals, including lanthanum (La) and zinc (Zn). We hypothesized that La-IP6 and Zn-IP6 may promote the elimination of ¹³⁷Cs from the body through the adsorption of La-IP6 and Zn-IP6 to ¹³⁷Cs in the gastrointestinal tract. Therefore, in this study, we evaluated the adsorptive capacity of La-IP6 and Zn-IP6 complexes with ¹³⁷Cs in vitro and in vivo. La-IP6 and Zn-IP6 complexes were stable in acidic solution (pH 1.2) at 37°C. In vitro binding assays indicated that La-IP6 and Zn-IP6 complexes adsorbed ¹³⁷Cs, with the adsorption capacity of Zn-IP6 to ¹³⁷Cs greater than that of La-IP6. To evaluate the usefulness of La-IP6 and Zn-IP6 in vivo, La-IP6 or Zn-IP6 was administrated to mice after intravenous injection of ¹³⁷Cs. However, the biodistribution of ¹³⁷Cs in the La-IP6 treated group and the Zn-IP6 treated group was nearly identical to the non-treated control group, indicating that La-IP6 and Zn-IP6 were not effective at promoting the elimination of ¹³⁷Cs in vivo.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 65 (3), 261-267, 2017

  The Pharmaceutical Society of Japan

Keywords

• cesium
• <i>myo</i>-inositol-hexakisphosphate
• decorporation
• Prussian blue

Details

• CRID: 1390001204178810880
• NII Article ID: 130005397367
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.c16-00792
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 028005831
• PubMed: 28250348
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028005831
• Web Site: https://www.jstage.jst.go.jp/article/cpb/65/3/65_c16-00792/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017326937
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed