Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study

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Author(s)

    • Murakami Keiko
    • Department of Hygiene and Public Health, Teikyo University School of Medicine
    • Kikuya Masahiro
    • Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University
    • Metoki Hirohito
    • Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University|Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University
    • Imai Yutaka
    • Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences
    • Ohkubo Takayoshi
    • Department of Hygiene and Public Health, Teikyo University School of Medicine
    • Asayama Kei
    • Department of Hygiene and Public Health, Teikyo University School of Medicine|Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences
    • Satoh Michihiro
    • Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University
    • Inoue Ryusuke
    • Medical Information Technology Center, Tohoku University Hospital
    • Hosaka Miki
    • Department of Development Promotion, Clinical Research, Innovation and Education Center, Tohoku University Hospital
    • Matsuda Ayako
    • Department of Hygiene and Public Health, Teikyo University School of Medicine
    • Nomura Kyoko
    • Department of Hygiene and Public Health, Teikyo University School of Medicine
    • Murakami Takahisa
    • Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University|Division of Aging and Geriatric Dentistry, Department of Oral Function and Morphology, Tohoku University Graduate School of Dentistry

Abstract

<p><b><i>Aim</i></b><b>: </b>Few studies have addressed stroke risk factors in older populations, particularly among the old-old. We examined differences in traditional risk factors for stroke among the old-old compared with the young-old in community-dwelling Japanese adults.</p><p><b><i>Methods</i></b><b>: </b>We followed 2,065 residents aged ≥ 60 years who had no history of stroke. Traditional risk factors for stroke were obtained from a self-administered questionnaire at baseline. We classified participants into two age categories, 60–74 years (<i>n</i>=1,502) and ≥ 75 years (<i>n</i>=563), and assessed whether traditional risk factors were differentially associated with stroke incidence according to age category. Hazard ratios were calculated by the Cox proportional hazards model, adjusting for confounding factors and competing risk of death.</p><p><b><i>Results</i></b><b>: </b>During a median follow-up of 12.8 and 7.9 years, 163 and 111 participants aged 60–74 and ≥ 75 years, respectively, developed a first stroke. Hypertension was consistently associated with increased risk of stroke, regardless of age category. Diabetes mellitus was associated with increased risk of stroke in those aged 60–74 years (hazard ratio, 1.50; 95% confidence interval, 1.00–2.25), but not in those aged ≥ 75 years (hazard ratio, 0.65; 95% confidence interval, 0.33–1.29), with significant interaction by age (<i>P</i>=0.035). No traditional risk factor other than hypertension was associated with stroke among those aged ≥ 75 years.</p><p><b><i>Conclusion</i></b><b>: </b>Those with hypertension had significantly higher stroke risk among old people, while diabetes mellitus was differentially associated with stroke according to age category. Our findings indicate the importance of different prevention strategies for stroke incidence according to age category.</p>

Journal

  • Journal of Atherosclerosis and Thrombosis

    Journal of Atherosclerosis and Thrombosis 24(3), 290-300, 2017

    Japan Atherosclerosis Society

Codes

  • NII Article ID (NAID)
    130005397989
  • Text Lang
    ENG
  • ISSN
    1340-3478
  • Data Source
    J-STAGE 
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