Lethal, Hemorrhagic, and Necrotic Effects of Montivipera bornmuelleri Venom

• ABI-RIZK Alain

  Faculty of Agricultural and Food Sciences, Holy Spirit University of Kaslik (USEK)

• RIMA Mohamad

  Azm Center for Research in Biotechnology and its Applications, Doctoral School of Sciences and Technology, Lebanese University

• HRAOUI BLOQUET Souad

  Faculty of Sciences II, Lebanese University

• SADEK Riyad

  Biology Department, American University of Beirut

• SLEIMAN Yvonne

  Faculty of Sciences, Holy Spirit University of Kaslik (USEK)

• FAJLOUN Ziad

  Azm Center for Research in Biotechnology and its Applications, Doctoral School of Sciences and Technology, Lebanese University

• HLEIHEL Walid

  Faculty of Sciences, Holy Spirit University of Kaslik (USEK)

書誌事項

タイトル別名

• Lethal, Hemorrhagic, and Necrotic Effects of <i>Montivipera bornmuelleri</i> Venom

抄録

Montivipera bornmuelleri is an endangered viper that has been described as endemic to the Lebanese mountains. The lethal dose 50% (LD₅₀) of M. bornmuelleri venom has been determined by performing intravenous, intraperitoneal (IP), and subcutaneous injections. However, to date, intramuscular injection has not been performed to determine LD₅₀, nor have the minimum hemorrhagic (MHD) or the minimum necrotic doses (MND) been evaluated. Thus, this study was conducted to complete the characterization of the M. bornmuelleri venom. Our results showed that intramuscularly injected LD₅₀ is around 5.39 mg/kg, and IP LD₅₀ is around 1.93 mg/kg. After intradermal injection, our findings showed significant necrotic and medium hemorrhagic activities, and MHD was around 250 μg/kg. By comparing with other local venomous snakes, these results indicate that the lethality of M. bornmuelleri venom is similar to that of Daboia palaestinae venom (IP LD₅₀=1.9 mg/kg) and is higher than that of Macrovipera lebetina venom (IP LD₅₀=7.58 mg/kg) and that the hemorrhagic activity of M. bornmuelleri venom is lower than that of the Macrovipera lebetina (MHD=200 μg/kg). On the other hand, necrotic activity was detected at low doses of injected venom: MND was estimated at 20 μg/kg. Altogether, our findings could extend the scope of characterization of M. bornmuelleri venom and provide useful data for further in vivo studies.

収録刊行物

• Ｃｕｒｒｅｎｔ　ｈｅｒｐｅｔｏｌｏｇｙ

  Ｃｕｒｒｅｎｔ　ｈｅｒｐｅｔｏｌｏｇｙ 36 (1), 58-62, 2017

  日本爬虫両棲類学会

キーワード

• Snake venom
• Lethal dose 50%
• Minimum hemorrhagic dose
• Minimum necrotic dose
• <i>Montivipera bornmuelleri</i>

詳細情報

• CRID: 1390001204714374784
• NII論文ID: 130005398695
• NII書誌ID: AA12246863
• DOI: 10.5358/hsj.36.58
• ISSN: 18811019
• ISSN: 13455834
• NDL書誌ID: 028000646
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028000646
• Web Site: http://www.bioone.org/doi/full-xml/10.5358/hsj.36.58
• 本文言語コード: en
• データソース種別:
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