<b>Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse </b><b>skin </b>

• ZHENG Miao

  Laboratory of Histology and Cytology, Department of Anatomy, Hokkaido University Graduate School of Medicine

• LEE Shinhye

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto Univer-sity

• TSUZUKI Satoshi

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto Univer-sity

• INOUE Kazuo

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto Univer-sity

• MASUDA Daisaku

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• YAMASHITA Shizuya

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• IWANAGA Toshihiko

  Laboratory of Histology and Cytology, Department of Anatomy, Hokkaido University Graduate School of Medicine

Abstract

The sebaceous glands secrete sebum to protect the epidermis and hairs by the oily products. The glands express several transporters and binding proteins for the production of fatty acids and uptake of their sources. The present immunohistochemical study examined the expression and localization of CD36, MCT1, FATP4, and E-FABP in the sebaceous glands, including the meibomian and preputial glands of mice. CD36 and MCT1 in sebaceous glands were largely co-localized along the plasma membrane of secretory cells, while they were separately expressed in the glandular portion of meibomian and preputial glands. Immunoreactivities for FATP4 and E-FABP appeared diffusely in the cytoplasm of secretory cells. Genetic deletion of CD36 did not affect the immunolocalization of the three other molecules. The sebaceous glands were judged to be useful for analyzing the functions and relation of fatty acid transporters and binding proteins.

Journal

• Biomedical Research

  Biomedical Research 37 (4), 265-270, 2016

  Biomedical Research Press

Keywords

• General Biochemistry, Genetics and Molecular Biology
• General Medicine

Details

• CRID: 1390001204901356544
• NII Article ID: 130005405216
• NII Book ID: AA00110128
• DOI: 10.2220/biomedres.37.265
• ISSN: 1880313X
• ISSN: 03886107
• HANDLE: 2115/63748
• PubMed: 27545003
• Web Site: https://www.jstage.jst.go.jp/article/biomedres/37/4/37_265/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017189861
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed