Estrus synchronization in microminipig using estradiol dipropionate and prostaglandin F₂α

• NOGUCHI Michiko

  Department of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan

• IKEDO Tomonobu

  Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan

• KAWAGUCHI Hiroaki

  Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan

• TANIMOTO Akihide

  Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan

書誌事項

タイトル別名

• Estrus synchronization in microminipig using estradiol dipropionate and prostaglandin F_2α

抄録

The induction of pseudopregnancy by the exogenous administration of estradiol dipropionate (EDP) was investigated in cyclic Microminipigs (MMpigs) and the effects of exogenous administration of prostaglandin (PG) F_2α on estrus exhibition were assessed in pseudopregnant MMpigs. In experiment 1, ovariectomized MMpigs were given a single intramuscular injection of 0.5, 1.5, or 2.5 mg of EDP. The estradiol-17β level at each of these doses was significantly higher 1 to 3 days after EDP administration than on the day of the injection. In experiment 2, animals were given 1.5 mg of EDP once at 9 to 12 days after the end of estrus (D0) and then no (1.5 mg × 1 group), one (D0 and D4; 1.5 mg × 2 group), or two (D0, D4 and D7; 1.5 mg × 3 group) additional treatments. The pseudopregnancy rate was significantly higher in the 1.5 mg × 3 than in the 1.5 mg × 1 group. In experiment 3, PGF_2α was administered twice between 26 and 28 days after EDP treatment to five pseudopregnant gilts with a 24-h interval between the two injections. Estrus after PGF_2α treatment and LH surge were observed in 100% and 80% pseudopregnant MMpigs, respectively. The interval from the day of the first PGF_2α treatment to the onset of estrus was 6.5 ± 0.2 days. These results indicate that multiple EDP treatments are required for induction of pseudopregnancy in MMpigs and estrus exhibition can be controlled in MMpigs by treatment with EDP and PGF_2α.

収録刊行物

• Journal of Reproduction and Development

  Journal of Reproduction and Development 62 (4), 373-378, 2016

  公益社団法人 日本繁殖生物学会

キーワード

• Estradiol dipropionate
• Estrus synchronization
• Microminipig
• Pseudopregnancy

詳細情報

• CRID: 1390001206337777152
• NII論文ID: 130005406792
• NII書誌ID: AA10936678
• DOI: 10.1262/jrd.2015-169
• ISSN: 13484400
• ISSN: 09168818
• NDL書誌ID: 027571418
• PubMed: 27151362
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027571418
• Web Site: https://www.jstage.jst.go.jp/article/jrd/62/4/62_2015-169/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017040411
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可