The Tohoku Medical Megabank Project: Design and Mission

• Kuriyama Shinichi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University International Research Institute of Disaster Science, Tohoku University

• Yaegashi Nobuo

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Nagami Fuji

  Tohoku Medical Megabank Organization, Tohoku University

• Arai Tomohiko

  Tohoku Medical Megabank Organization, Tohoku University

• Kawaguchi Yoshio

  Tohoku Medical Megabank Organization, Tohoku University

• Osumi Noriko

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Sakaida Masaki

  Tohoku Medical Megabank Organization, Tohoku University

• Suzuki Yoichi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Nakayama Keiko

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Hashizume Hiroaki

  Tohoku Medical Megabank Organization, Tohoku University

• Tamiya Gen

  Tohoku Medical Megabank Organization, Tohoku University

• Kawame Hiroshi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Suzuki Kichiya

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Hozawa Atsushi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Nakaya Naoki

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Kikuya Masahiro

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Metoki Hirohito

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Tsuji Ichiro

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Fuse Nobuo

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Kiyomoto Hideyasu

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Sugawara Junichi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Tsuboi Akito

  Tohoku Medical Megabank Organization, Tohoku University Tohoku University Hospital, Tohoku University Graduate School of Dentistry, Tohoku University

• Egawa Shinichi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University International Research Institute of Disaster Science, Tohoku University Tohoku University Hospital, Tohoku University

• Ito Kiyoshi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University International Research Institute of Disaster Science, Tohoku University Tohoku University Hospital, Tohoku University

• Chida Koichi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University International Research Institute of Disaster Science, Tohoku University Tohoku University Hospital, Tohoku University

• Ishii Tadashi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Tomita Hiroaki

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University International Research Institute of Disaster Science, Tohoku University Tohoku University Hospital, Tohoku University

• Taki Yasuyuki

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Institute of Development, Aging and Cancer, Tohoku University

• Minegishi Naoko

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Ishii Naoto

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Yasuda Jun

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Igarashi Kazuhiko

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Shimizu Ritsuko

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Nagasaki Masao

  Tohoku Medical Megabank Organization, Tohoku University

• Koshiba Seizo

  Tohoku Medical Megabank Organization, Tohoku University

• Kinoshita Kengo

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Information Sciences, Tohoku University

• Ogishima Soichi

  Tohoku Medical Megabank Organization, Tohoku University

• Takai-Igarashi Takako

  Tohoku Medical Megabank Organization, Tohoku University

• Tominaga Teiji

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Tanabe Osamu

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

• Ohuchi Noriaki

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Shimosegawa Toru

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Kure Shigeo

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Tanaka Hiroshi

  Tohoku Medical Megabank Organization, Tohoku University

• Ito Sadayoshi

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University Tohoku University Hospital, Tohoku University

• Hitomi Jiro

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University

• Tanno Kozo

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University

• Nakamura Motoyuki

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University

• Ogasawara Kuniaki

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University

• Kobayashi Seiichiro

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University

• Sakata Kiyomi

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University

• Satoh Mamoru

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University Institute for Biomedical Science, Iwate Medical University

• Shimizu Atsushi

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University

• Sasaki Makoto

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University Institute for Biomedical Science, Iwate Medical University

• Endo Ryujin

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University

• Sobue Kenji

  Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University Institute for Biomedical Science, Iwate Medical University

• Tohoku Medical Megabank Project Study Group the

• Yamamoto Masayuki

  Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University

Bibliographic Information

Other Title

• The Tohoku Medical Megabank Project: deesign and mission

Abstract

The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and follow them for at least 5 years. The TMM BirThree Cohort Study will recruit participants from 2013 to 2017 and follow them for at least 4 years. For children, the ToMMo Child Health Study, which adopted a cross-sectional design, was also started in November 2012 in Miyagi Prefecture. An integrated biobank will be constructed based on the two prospective cohort studies, and ToMMo and IMM will investigate the chronic medical impacts of the GEJE. The integrated biobank of TMM consists of health and clinical information, biospecimens, and genome and omics data. The biobank aims to establish a firm basis for personalized healthcare and medicine, mainly for diseases aggravated by the GEJE in the two prefectures. Biospecimens and related information in the biobank will be distributed to the research community. TMM itself will also undertake genomic and omics research. The aims of the genomic studies are: 1) to construct an integrated biobank; 2) to return genomic research results to the participants of the cohort studies, which will lead to the implementation of personalized healthcare and medicine in the affected areas in the near future; and 3) to contribute the development of personalized healthcare and medicine worldwide. Through the activities of TMM, we will clarify how to approach prolonged healthcare problems in areas damaged by large-scale disasters and how useful genomic information is for disease prevention.

Journal

• Journal of Epidemiology

  Journal of Epidemiology 26 (9), 493-511, 2016

  Japan Epidemiological Association

Keywords

• the Great East Japan Earthquake
• Tohoku Medical Megabank Project
• cohort study
• biobank
• genomic research

Details

• CRID: 1390001204474441600
• NII Article ID: 130005409018
• DOI: 10.2188/jea.je20150268
• ISSN: 13499092
• ISSN: 09175040
• PubMed: 27374138
• Web Site: https://www.jstage.jst.go.jp/article/jea/26/9/26_JE20150268/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017225012
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
  • Integbio
• Abstract License Flag: Disallowed