Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis

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Author(s)

    • Noda Tomoko
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Katsuno Masahisa
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Sobue Gen
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Iijima Masahiro
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Noda Seiya
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Maeshima Shinya
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Kimura Seigo
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Koike Haruki
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Ishigaki Shinsuke
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    • Iguchi Yohei
    • Department of Neurology, Nagoya University Graduate School of Medicine, Japan

Abstract

<p><b>Objective </b>An association has been reported between inflammatory myopathies (IMs), which include polymyositis (PM) and dermatomyositis (DM), and malignancy, and the concept of cancer-associated myositis (CAM) was recently proposed. We herein attempted to determine the features and etiologies of these myopathies. </p><p><b>Methods </b>We analyzed the gene expression levels via microarray and real-time quantitative reverse transcription polymerase chain reaction analyses to identify genes that were specifically upregulated or downregulated with suspected inflammatory involvement and verified the microarray data via an immunohistochemical (IHC) analysis in additional cases. </p><p><b>Patients </b>We selected 14 patients with the following conditions: PM without malignancy (n=3), DM without malignancy (n=3), CAM (n=3), and Controls (no pathological changes or malignancy; n=5). </p><p><b>Results </b>PM was distinct from DM and CAM in a clustering analysis and exhibited the highest numbers of overexpressed genes and specific pathologies in a gene ontology analysis. The IHC analysis confirmed the gene expression results. </p><p><b>Conclusion </b>PM is associated with severe inflammatory pathological findings, primarily in the cell-mediated immune system. DM and CAM exhibit similarities in the gene expression and IHC results, which suggest that humoral immunity is the main etiology for both myopathies, indicating the importance of cancer screening in patients with IMs, particularly DM. </p>

Journal

  • Internal Medicine

    Internal Medicine 55(18), 2571-2580, 2016

    The Japanese Society of Internal Medicine

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