Effect of right atrial contraction on prosthetic valve function in a mechanical pulmonary circulatory system

• TSUBOKO Yusuke

  Graduate School of Biomedical Engineering, Tohoku University

• SHIRAISHI Yasuyuki

  Department of PreClinical Evaluation, PreClinical Research Center, Institute of Development, Aging and Cancer, Tohoku University Department of Medical Engineering and Cardiology, PreClinical Research Center, Institute of Development, Aging and Cancer, Tohoku University

• MATSUO Satoshi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Tohoku University

• YAMADA Akihiro

  Department of Medical Engineering and Cardiology, PreClinical Research Center, Institute of Development, Aging and Cancer, Tohoku University

• MIURA Hidekazu

  Department of Medical Engineering and Cardiology, PreClinical Research Center, Institute of Development, Aging and Cancer, Tohoku University

• SHIGA Takuya

  Department of Medical Engineering and Cardiology, PreClinical Research Center, Institute of Development, Aging and Cancer, Tohoku University

• HASHEM Mohamed Omran

  Department of Medical Engineering and Cardiology, PreClinical Research Center, Institute of Development, Aging and Cancer, Tohoku University

• YAMBE Tomoyuki

  Graduate School of Biomedical Engineering, Tohoku University Department of PreClinical Evaluation, PreClinical Research Center, Institute of Development, Aging and Cancer, Tohoku University Department of Medical Engineering and Cardiology, PreClinical Research Center, Institute of Development, Aging and Cancer, Tohoku University

抄録

Improving the inflow characteristics of the right ventricular function and pulmonary circulatory hemodynamics was essential for more precise evaluation of newly designed heart valves. To examine a pulmonary hemodynamics, the authors have been developing a pulmonary mechanical mock circulatory system. In this study, the pneumatically driven right atrium model was newly developed for clarifying the effect of atrial contraction on the dynamic behavior of pulmonary prosthetic valves. We focused on the hemodynamic behavior of the outflow mechanical heart valve of the right ventricle that could be affected by the right atrial dynamic motion. A medical-grade bileaflet valve was employed and installed into the outflow portion of the right ventricle model and examined its changes in hemodynamic behavior caused by the active right atrial contraction. With the active atrial contraction, hemodynamic waveforms of either the right ventricle or atrium were obtained using the modified pulmonary mock circulatory system. The characteristics with atrial contraction were well simulated as the natural hemodynamics. The right ventricular output increased by around 5% and the peak regurgitant flow at the moment of valve closing significantly decreased by the presence of the atrial contraction. Our mechanical circulatory system could simulate the end-diastolic right ventricular inflow characteristics. We found that the atrial contraction under the low pressure condition such as pulmonary circulation promoted earlier valve closing and prolonged closing duration of prosthetic valve. The simulation of right atrial contraction was important in the quantitative examination of right heart prosthetic valves for congenital heart malformation.

収録刊行物

• Journal of Biomechanical Science and Engineering

  Journal of Biomechanical Science and Engineering 11 (3), 15-00356-15-00356, 2016

  一般社団法人 日本機械学会

キーワード

• Pulmonary mechanical circulatory system
• Atrial contraction
• Pulmonary arterial valve
• Pneumatically driven atrium model
• Congenital heart disease

詳細情報

• CRID: 1390282680239821184
• NII論文ID: 130005414976
• DOI: 10.1299/jbse.15-00356
• ISSN: 18809863
• Web Site: https://www.jstage.jst.go.jp/article/jbse/11/3/11_15-00356/_pdf
• 本文言語コード: en
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