分子標的治療薬併用放射線療法が奏功した口蓋MALTリンパ腫の1例

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  • A case of MALT lymphoma of the palate successfully treated by radiotherapy and a molecular-targeted drug
  • ブンシ ヒョウテキ チリョウヤク ヘイヨウ ホウシャセン リョウホウ ガ ソウコウ シタ コウガイ MALT リンパシュ ノ 1レイ

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<p>Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) often occurs in the stomach. Although rare, MALT lymphoma can also occur in the oral cavity. MALT lymphoma is a low-grade lymphoma that can gradually transform into diffuse giant B cell lymphoma. Therefore, local therapy must be administered for localized lesions. A few cases of MALT lymphoma of the palate have been reported, but treatment strategies remain to be established. We report a case of MALT lymphoma in a 74-year-old woman who was successfully treated with radiotherapy and the molecular-targeted drug rituximab. The patient was examined at our department for a tumor extending from the left soft palate to the hard palate. The 20 × 20 mm lesion was painless and slightly elevated with a smooth surface. A pathological diagnosis of MALT lymphoma was established on biopsy. Treatment comprised 39.6 Gy of radiation followed by 8 courses of the molecular-targeted drug rituximab. The tumor showed a complete response, and there were no serious treatment-related adverse events. The patient has remained recurrence-free for 4 years.</p>

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