The involvement of central nervous system histamine receptors in psychological stress-induced exacerbation of allergic airway inflammation in mice

• Miyasaka Tomomitsu

  Department of Pathophysiology, Tohoku Pharmaceutical University

• Okuyama-Dobashi Kaori

  Department of Pathophysiology, Tohoku Pharmaceutical University Department of Microbiology, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering (Faculty of Medicine), University of Yamanashi

• i Masuda Chiaki

  Department of Pathophysiology, Tohoku Pharmaceutical University

• Iwami Shunya

  Department of Pathophysiology, Tohoku Pharmaceutical University

• Sato Miki

  Department of Pathophysiology, Tohoku Pharmaceutical University

• Mizoguchi Hirokazu

  Department of Physiology and Anatomy, Tohoku Pharmaceutical University

• Kawano Tasuku

  Department of Pathophysiology, Tohoku Pharmaceutical University

• Ohkawara Yuichi

  Department of Pathophysiology, Tohoku Pharmaceutical University

• Sakurada Shinobu

  Department of Physiology and Anatomy, Tohoku Pharmaceutical University

• Takayanagi Motoaki

  Department of Pathophysiology, Tohoku Pharmaceutical University

• Ohno Isao

  Department of Pathophysiology, Tohoku Pharmaceutical University

Abstract

Background: Psychological stress is one of the major risk factors for asthma exacerbation. Although histamine in the brain acts as an excitatory and inhibitory neurotransmitter associated with psychological stress, the contribution of brain histamine to psychological stress-induced exacerbation of asthma remains unclear. The objective of this study was to investigate the role of histamine receptors in the CNS on stress induced asthma aggravation. Methods: We monitored the numbers of inflammatory cells and interleukin (IL)-13 levels in bronchoalveolar lavage fluid, airway responsiveness to inhaled methacholine, mucus secretion in airway epithelial cells, and antigen-specific IgE contents in sera in a murine model of stress-induced asthma treated with epinastine (an H₁R antagonist), thioperamide (an H_3/4R antagonist), or solvent. Results: All indicators of stress-induced asthma exacerbation were significantly reduced in stressed mice treated with epinastine compared with those treated with solvent, whereas treatment with thioperamide did not reduce the numbers of inflammatory cells in the stressed mice. Conclusions: These results suggest that H₁R, but not H_3/4R, may be involved in stress-induced asthma exacerbations in the central nervous system.

Journal

• Allergology International

  Allergology International 65 (Supplement.1), 38-44, 2016

  Japanese Society of Allergology

Keywords

• Bronchial asthma, Epinastine, Histamine receptors, Psychological stress, Thioperamide

Details

• CRID: 1390282679611088384
• NII Article ID: 130005418900
• DOI: 10.1016/j.alit.2016.05.015
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893016300922?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893016300922?httpAccept=text/plain
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed