REVIEW FOR THE 2015 SATO AWARD : Heart Development, Diseases, and Regeneration : New Approaches From Innervation, Fibroblasts, and Reprogramming

• Ieda Masaki

  Department of Cardiology, Keio University School of Medicine AMED-PRIME

書誌事項

タイトル別名

• Heart Development, Diseases, and Regeneration　– New Approaches From Innervation, Fibroblasts, and Reprogramming –

抄録

It is well known that cardiac function is tightly controlled by neural activity; however, the molecular mechanism of cardiac innervation during development and the relationship with heart disease remain undetermined. My work has revealed the molecular networks that govern cardiac innervation and its critical roles in heart diseases such as silent myocardial ischemia and arrhythmias. Cardiomyocytes proliferate during embryonic development, but lose their proliferative capacity after birth. Cardiac fibroblasts are a major source of cells during fibrosis and induce cardiac hypertrophy after myocardial injury in the adult heart. Despite the importance of fibroblasts in the adult heart, the role of fibroblasts in embryonic heart development was previously not determined. I demonstrated that cardiac fibroblasts play important roles in myocardial growth and cardiomyocyte proliferation during embryonic development, and I identified key paracrine factors and signaling pathways. In contrast to embryonic cardiomyocytes, adult cardiomyocytes have little regenerative capacity, leading to heart failure and high mortality rates after myocardial infarction. Leveraging the knowledge of developmental biology, I identified cardiac reprogramming factors that can directly convert resident cardiac fibroblasts into cardiomyocytes for heart regeneration. These findings greatly improved our understanding of heart development and diseases, and provide a new strategy for heart regenerative therapy. (Circ J 2016; 80: 2081–2088)

収録刊行物

• Circulation Journal

  Circulation Journal 80 (10), 2081-2088, 2016

  一般社団法人 日本循環器学会

キーワード

• Cardiac fibroblast
• Development
• Direct reprogramming
• Nervous system
• Regeneration

詳細情報

• CRID: 1390282680083414400
• NII論文ID: 130005419072
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-16-0815
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 027611790
• PubMed: 27599529
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027611790
• Web Site: https://www.jstage.jst.go.jp/article/circj/80/10/80_CJ-16-0815/_pdf
• 本文言語コード: en
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