生検では癌腫が認められなかった多形腺腫由来癌の1例  [in Japanese] A Case of Carcinoma Ex Pleomorphic Adenoma Lacking a Carcinoma Component in a Biopsy Specimen  [in Japanese]

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Author(s)

    • 鳴瀬 智史 NARUSE TOMOFUMI
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 柳本 惣市 YANAMOTO SOUICHI
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 河野 俊広 KAWANO TOSHIHIRO
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野|琉球大学大学院医学研究科顎顔面口腔機能再建学講座 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences|Department of Oral and Maxillofacial Functional Rehabilitaion, Graduate School of Medicine, University of the Ryukyu
    • 山下 健太郎 YAMASHITA KENTARO
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 藤田 修一 FUJITA SHUICHI
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔病理学分野 Department of Oral Pathology and Bone Metabolism Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 梅田 正博 UMEDA MASAHIRO
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences

Abstract

We describe our experience with a case of carcinoma ex pleomorphic adenoma. A 54-year-old woman was referred to our hospital because of a painless mass of the left palate that had been present for 10 years. Clinical examination revealed a 20×18×12-mm well-defined, elastic soft mass in the left region of the soft palate. The preoperative incisional biopsy showed pleomorphic adenoma without a malignant component, but the removed tumor included small foci of salivary duct carcinoma within pleomorphic adenoma. After the histological diagnosis of pleomorphic adenoma from the biopsy, the lesion was excised under general anesthesia. Histopathological examination of the excised specimen revealed an encapsulated tumor composed of solid and duct-like proliferation with hyalinous and myxoid extracellular matrices like an incisional biopsy. However, small malignant areas were noticed within the tumor. The carcinomatous elements were composed of nests of cribriform patterns and ductal structures containing necrotic tissues in the lumen. These structures were comprised of large epithelial cells with eosinophilic cytoplasmic granules and enlarged hyperchromatic nuclei, and peripheral mono-layered flattened cells without atypia. The eosinophilic cells and peripheral flattened cells immunohistochemically demonstrated phenotypes of duct luminal cell and myoepithelial cell, respectively. Based on the histological and immunohistochemical findings, the malignant component was diagnosed as salivary duct carcinoma. The present tumor was finally diagnosed as carcinoma ex pleomorphic adenoma. No signs of recurrence have been observed 3 years after surgery.

Journal

  • Japanese Journal of Oral Diagnosis / Oral Medicine

    Japanese Journal of Oral Diagnosis / Oral Medicine 29(2), 60-67, 2016

    The Japanese Society of Oral Diagnosis / Oral Medicine

Codes

  • NII Article ID (NAID)
    130005421120
  • Text Lang
    JPN
  • ISSN
    0914-9694
  • Data Source
    J-STAGE 
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