Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus

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Author(s)

    • Hirai Hiroyuki
    • Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Japan
    • Midorikawa Sanae
    • Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Japan|Department of Radiation Health Management, Fukushima Medical University, Japan
    • Suzuki Shinichi
    • Department of Thyroid and Endocrinology, Fukushima Medical University, School of Medicine, Japan
    • Sasano Hironobu
    • Department of Pathology, Tohoku University, Graduate School of Medicine, Japan
    • Watanabe Tsuyoshi
    • Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Japan
    • Satoh Hiroaki
    • Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Japan

Abstract

<p>We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 μg/day. Histologically, somatostatin immunoreactivity was detected and the somatostatin levels were elevated in the serum-like fluid obtained from the tumor. Clinicians should be aware of the possible occurrence of simultaneous ectopic hormone secretion in patients with pheochromocytoma. </p>

Journal

  • Internal Medicine

    Internal Medicine 55(20), 2985-2991, 2016

    The Japanese Society of Internal Medicine

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