Versatile Ruthenium Complex “RuPCY” for Directed Catalytic Hydrogen Management in Organic Synthesis

• Takada Yuki

• Iida Megumi

• Iida Kazuki

• Miura Takashi

• Saito Susumu

  Graduate School of Science, Nagoya University

抄録

The ruthenium (Ru) precatalyst complex dichlorobis[2-[(dicyclohexylphosphino-κP)methyl]pyridine-κN]ruthenium(II) (RuPCY), first developed by us, was shown to be useful not only for the catalytic hydrogenation of inert carboxylic acid derivatives including amides and esters, but also for the catalytic dehydrogenation of primary (1°) and secondary (2°) alcohols and subsequent reactions. RuPCY is versatile, and different Ru catalysts derived therefrom are quite useful for realizing a variety of indiscrete/discrete catalytic hydrogen management (HyMA) reactions. The sequential use of different starting materials and different catalysts (all derived from RuPCY) permits otherwise challenging orthogonal HyMA processes. This accommodates, for example, a salt-free access and/or shortcut to synthetic intermediates of pharmaceutically important substances such as donepezil (Aricept^®) and atorvastatin (Lipitor^®).

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 74 (11), 1078-1089, 2016

  公益社団法人 有機合成化学協会

キーワード

• Organic Chemistry

詳細情報

• CRID: 1390001205340050432
• NII論文ID: 130005433322
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.74.1078
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 027740231
• Web Site: http://id.ndl.go.jp/bib/027740231
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027740231
• Web Site: https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/74/11/74_1078/_pdf
• 本文言語コード: en
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