A Membrane-integrated Microfluidic Device to Study Permeation of Nanoparticles through Straight Micropores toward Rational Design of Nanomedicines

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  • SASAKI Naoki
    Department of Chemical and Biological Sciences, Faculty of Science, Japan Women’s University Department of Applied Chemistry, Faculty of Science and Engineering, Toyo University
  • TATANOU Mariko
    Department of Chemical and Biological Sciences, Faculty of Science, Japan Women’s University
  • SUZUKI Tomoko
    Department of Chemical and Biological Sciences, Faculty of Science, Japan Women’s University
  • ANRAKU Yasutaka
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo
  • KISHIMURA Akihiro
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo Center for Molecular Systems, Kyushu University Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • KATAOKA Kazunori
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo
  • SATO Kae
    Department of Chemical and Biological Sciences, Faculty of Science, Japan Women’s University

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Abstract

Nanoparticles have been widely utilized to deliver drugs from blood vessels to target tissues. A crucial issue concerning nanoparticle-based drug delivery is to discuss the relationship between experimentally-obtained permeability and physical parameters. Although nanoparticles can permeate vascular pores, because the size and shape of the pores are essentially non-uniform, conventional animal testing and recent cell-based microfluidic devices are unable to precisely evaluate the effects of physical parameters (e.g. pore size and nanoparticle size) on permeation. In this study, we present a membrane-integrated microfluidic device to study permeation of nanoparticles through straight micropores. Porous membranes possessing uniform straight pores were utilized. The effects of pore size and pressure difference across the pores on nanoparticle permeation were examined. The experimentally determined permeability coefficient of 1.0 μm-pore membrane against 100 nm-diameter nanoparticles agreed well with the theoretical value obtained for convectional permeation. Our method can be utilized to clarify the relationship between the experimentally-obtained permeability and physical parameters, and will help rational design of nanomedicines.

Journal

  • Analytical Sciences

    Analytical Sciences 32 (12), 1307-1314, 2016

    The Japan Society for Analytical Chemistry

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