Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis

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    • Yamakawa Mitsunori
    • Department of Pathological Diagnostics, Yamagata University Faculty of Medicine
    • Yoshino Tadashi
    • Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Matsumura Itaru
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine


<p>Langerhans cell (LC) histiocytosis (LCH) and LC sarcoma (LCS) are proliferative processes consisting of cells having morphologic and phenotypic features of Langerhans cells (LCs), although the latter may have lost some of these features. Because neoplastic nature of LCH as well as LCS is more likely by recent studies, a category of LC hyperplasia can be better characterized. LCH and LCS are rarely seen in daily pathology practice, but it is important to accurately characterize these lesions. For this purpose, an outline covering proliferations of LC and related cells was constructed. The scheme of this outline is based especially on evaluating borderline lesions, neoplastic trans-differentiation, and degree of similarity with the normal counter-parts. In addition, the organization and update of the current classification scheme for histiocytic and dendritic-cell proliferations is presented.</p>


  • Journal of Clinical and Experimental Hematopathology

    Journal of Clinical and Experimental Hematopathology 56(2), 109-118, 2016

    The Japanese Society for Lymphoreticular Tissue Research


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