Reduced Sampling Size with Nanopipette for Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging
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- Kohigashi Tsuyoshi
- Faculty of Chemistry, Materials and Bioengineering, Kansai University
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- Otsuka Yoichi
- Department of Chemistry, Graduate School of Science, Osaka University
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- Shimazu Ryo
- Faculty of Chemistry, Materials and Bioengineering, Kansai University
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- Matsumoto Takuya
- Department of Chemistry, Graduate School of Science, Osaka University
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- Iwata Futoshi
- Faculty of Engineering, Shizuoka University
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- Kawasaki Hideya
- Faculty of Chemistry, Materials and Bioengineering, Kansai University
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- Arakawa Ryuichi
- Faculty of Chemistry, Materials and Bioengineering, Kansai University
抄録
<p>Mass spectrometry imaging (MSI) with ambient sampling and ionization can rapidly and easily capture the distribution of chemical components in a solid sample. Because the spatial resolution of MSI is limited by the size of the sampling area, reducing sampling size is an important goal for high resolution MSI. Here, we report the first use of a nanopipette for sampling and ionization by tapping-mode scanning probe electrospray ionization (t-SPESI). The spot size of the sampling area of a dye molecular film on a glass substrate was decreased to 6 μm on average by using a nanopipette. On the other hand, ionization efficiency increased with decreasing solvent flow rate. Our results indicate the compatibility between a reduced sampling area and the ionization efficiency using a nanopipette. MSI of micropatterns of ink on a glass and a polymer substrate were also demonstrated.</p>
収録刊行物
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- Mass Spectrometry
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Mass Spectrometry 5 (2), S0054-S0054, 2016
一般社団法人 日本質量分析学会
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詳細情報 詳細情報について
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- CRID
- 1390282680392937472
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- NII論文ID
- 130005435620
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- ISSN
- 21865116
- 2187137X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可