Growth of <i>Candida albicans</i> in Peripheral Parenteral Nutrition Solutions Supplemented with Biotin

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  • OHARA Hiroshi
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Ohu University
  • MATSUZAKI Tetsuya
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Ohu University
  • HAYASAKA Masataka
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Ohu University

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  • ビオチン添加末梢静脈栄養輸液における<i>Candida albicans</i>の増殖性に関する研究
  • ビオチン添加末梢静脈栄養輸液におけるCandida albicansの増殖性に関する研究
  • ビオチン テンカ マッショウ ジョウミャク エイヨウユエキ ニ オケル Candida albicans ノ ゾウショクセイ ニ カンスル ケンキュウ

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Abstract

<p>Candida albicans (C. albicans) is one of major causes of catheter-related blood stream infections (CRBSI) and causes a higher mortality. It was reported that adding multivitamins to parenteral nutrition solutions promotes the growth of C. albicans. In these days, amino acid, water-soluble vitamin-added comprehensive electrolyte infusion was released in Japan. In particular, biotin has been reported to be closely-involved in the growth of fungus, there is concern regarding the risk of CRBSI. In this study, the effects of biotin or the other water-soluble vitamins (SVs) on the growth of C. albicans in Peripheral Parenteral Nutrition (PPN) solutions were investigated. Two commercial PPN solutions, [BFLUID® (BF) ] and, [PAREPLUS® (PP) ] were used as test solutions. Furthermore, BF was supplemented with biotin or the other SVs to prepare test solutions [BF-biotin (+) and BF-biotin (-), respectively]. A certain number of C. albicans was added to each test solutions in sterile plastic flasks, and all flasks were allowed to stand at room temperature. The number of colony forming units (CFU/mL) was counted at 0, 24, 48, and 72 hours after the addition of C. albicans. C. albicans increased rapidly in PP and BF-Biotin (+), but increased slowly in BF and BF-Biotin (-). These results suggest that biotin promotes the growth of C. albicans in PPN solutions, and that the risk of CRBSI might increase in the PPN solution containing biotin rather than conventional PPN solutions, if contamination by C. albicans occurs.</p>

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