Development of a Multichannel Dialysis Microchip for Bioassay of Drug Efficacy and Retention
-
- SAKUTA Yu
- School of Science and Technology, Gunma University
-
- TSUNODA Kin-ichi
- School of Science and Technology, Gunma University
-
- SATO Kiichi
- School of Science and Technology, Gunma University
この論文をさがす
抄録
Here, we developed a multichannel dialysis microchip having three sets of dialysis systems, which consisted of three independent circulation channels with a common micropump. Each dialysis system was composed of a pneumatic micropump (heart), dialysis unit (renal corpuscle), and cell culture chamber (drug target) as well as circulation and dialysate channels to mimic the circulation system. Small molecules were successfully separated in parallel from macromolecules at the dialysis components. Anticancer tests using this microchip showed results that considered both serum protein-binding nature and drug activity. In the anticancer bioassay, the multichannel chip showed similar reproducible and reliable results as those of the single-channel system but with higher throughput.
収録刊行物
-
- Analytical Sciences
-
Analytical Sciences 33 (3), 391-394, 2017
社団法人 日本分析化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204260599424
-
- NII論文ID
- 130005439454
-
- NII書誌ID
- AA10500785
-
- ISSN
- 13482246
- 09106340
-
- NDL書誌ID
- 028036889
-
- PubMed
- 28302984
-
- Web Site
- http://id.ndl.go.jp/bib/028036889
- https://ndlsearch.ndl.go.jp/books/R000000004-I028036889
- https://link.springer.com/content/pdf/10.2116/analsci.33.391.pdf
- https://link.springer.com/article/10.2116/analsci.33.391/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/33/3/33_391/_pdf
- https://search.jamas.or.jp/link/ui/2017327094
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可