海馬CA1シナプスに化学的に誘導したLTPおよびLTDの性質について

• 藤井 聡

  山形大・医・第２生理 科学技術振興機構

• 黒田 洋一郎

  科学技術振興機構

• 御子柴 克彦

  東京大・医科研・脳神経発生分化

• 佐々木 寛

  山形大・医・第２生理

• 金子 健也

  山形大・医・第２生理

• 山崎 Yoshihiko

  山形大・医・第２生理

• 加藤 宏司

  山形大・医・第２生理

書誌事項

タイトル別名

• A chemical LTP and LTD induced by activation of metabotropic glutamate receptors in hippocampal CA1 neurons

抄録

In CA1 neurons of guinea pig hippocampal slices, long-term depression (LTD) was induced in the field EPSP response in the absence of test synaptic inputs (1 stimulus every 20 sec) by application of the metabotropic glutamate receptor (mGluR) agonist, aminocyclopentane-1S, 3R-dicarboxylic acid (ACPD). This effect was blocked and long-term potentiation (LTP) was induced by co-application of N-methyl-D-aspartate (NMDA) during ACPD perfusion (ACPD/NMDA-induced LTD). These results indicate that the state of NMDA receptor activation during ACPD perfusion determines whether LTP or LTD is induced in hippocampal CA1 neurons. Co-application of an inositol 1, 4, 5-trisphosphate (IP3) receptor inhibitor, 2-aminotheoxydiphenyl borate, during ACPD application had no effect on the ACPD/NMDA-induced LTP, but increased the magnitude of the ACPD-induced LTD, suggesting that the ACPD/NMDA-induced LTP involves NMDA receptors, but not IP3 receptors, whereas the converse applies to the ACPD-induced LTD. [Jpn J Physiol 54 Suppl:S152 (2004)]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2004 (0), S152-S152, 2004

  一般社団法人　日本生理学会

キーワード

• LTP
• LTD
• hippocampus
• NMDA receptors
• IP3 receptors

詳細情報

• CRID: 1390001205727273216
• NII論文ID: 130005446903
• DOI: 10.14849/psjproc.2004.0_s152_2
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可