覚醒下ラットにおけるピロカルピン誘発唾液と渇き

• 佐藤 奈緒

  九歯大・歯・生命科学 九歯大・歯・口腔治療

• 小野 堅太郎

  九歯大・歯・生命科学

• 本田 栄子

  九歯大・歯・生命科学

• 芳賀 健輔

  九歯大・歯・口腔治療

• 横田 誠

  九歯大・歯・口腔治療

• 稲永 清敏

  九歯大・歯・生命科学

書誌事項

タイトル別名

• Pilocarpine-induced salivation and thirst in conscious rats

抄録

Interestingly, pilocarpine, which is used as a sialogogue for the treatment of dry mouth, induces drinking behavior though muscarinic receptors in the central nervous system when applied peripherally. Although studies from anesthetized rats suggested that the pilocarpine administration affects the central nervous system and modulates salivary secretion, the mechanism is not clear. In this experiment, pilocarpine was applied intracerebroventricularly (ICV) or intraperitoneally (IP) in conscious rats, and salivary secretion and water intake were measured. IP-injected pilocarpine increased salivary secretion at 0.4-12 μmol/mL/kg and water intake at 1.2-12 μmol/mL/kg, in dose-dependent manners. Atropine injected by ICV in advance suppressed the pilocarpine-induced water intake while it did not the salivary secretion. Further, ICV-injected pilocarpine increased water intake in a dose-dependent manner while it had no effects on salivary secretion. Atropine injected by ICV in advance blocked the water intake by ICV pilocarpine. These results suggest that while peripherally-applied pilocarpine acts centrally the thirst center and induces drinking behavior, the central action is not enough to modulate salivary secretion in conscious rats. [Jpn J Physiol 55 Suppl:S112 (2005)]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2005 (0), S112-S112, 2005

  一般社団法人　日本生理学会

キーワード

• saliva
• water intake
• pilocarpine
• ICV

詳細情報

• CRID: 1390282680706030848
• NII論文ID: 130005447482
• DOI: 10.14849/psjproc.2005.0_s112_2
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可