エストロゲン補充が卵巣摘出ラットの摂食量および摂食パターンに及ぼす影響
書誌事項
- タイトル別名
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- Effect of estrogen replacement on food intake behavior in ovariectomized rats
抄録
To gain better insights into the mechanisms for estrogen-induced attenuation of food intake, we examined the effect of estradiol replacement in ovariectomized rats on diurnal feeding and hypothalamic c-Fos expression patterns, and on feeding and hypothalamic c-Fos expression responses to 48-h fasting. Seven-week-old rats were ovariectomized and were assigned into estradiol- (E2-T) and placebo-treated (Pla-T) groups. The daily food intake and body weight gain in the E2-T group were significantly less than the Pla-T group. Food intake during both light and dark phases in the Pla-T group was larger than the E2-T group, but the difference between the two groups was more prominent during light phase. In addition, the fractional food intake during light phase was 28% in E2-T rats, and 39% in Pla-T rats. The number of c-Fos ir cells in suprachiasmatic nucleus (SCN) in the Pla-T group was not different from the E2-T group at the beginning of dark phase, but was less than the E2-T group at the beginning of light phase. The number of c-Fos expressing cells at the arcuate nucleus (ARC) in E2-T rats was less than Pla-T rats in both light and dark phases. The feeding response and c-Fos expression at ARC following 48 h fasting were not different between the two groups. These results suggest that 1) estrogen tonically inhibits ARC neuronal activity and feeding, 2) estrogen might play a role in the generation of circadian SCN neuronal activity rhythm and attenuation of feeding during light phase, and 3) estrogen modulates spontaneous feeding but does not influence fasting-induced feeding response. [Jpn J Physiol 55 Suppl:S201 (2005)]
収録刊行物
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- 日本生理学会大会発表要旨集
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日本生理学会大会発表要旨集 2005 (0), S201-S201, 2005
一般社団法人 日本生理学会
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