CaMK4ノックアウトマウスの包括的行動解析

• 短田 浩一

  京大院・医・先端領域融合医学研究機構 京都府立医科大学大学院発達小児医学

• 山崎 信幸

  京大院・医・先端領域融合医学研究機構

• 遠山 桂子

  京大院・医・先端領域融合医学研究機構

• 阪上 洋行

  東北大学大学院医学研究科細胞生物学講座

• 宮川 剛

  京大院・医・先端領域融合医学研究機構

書誌事項

タイトル別名

• Comprehensive behavioral analysis of Ca<SUP>2+</SUP>/calmodulin-dependent protein kinase 4 knockout mouce

抄録

Ca²⁺/calmodulin-dependent protein kinase 4(CaMK4)is a protein kinase that activates the transcription factor, cAMP response- element binding protein (CREB). CaMK4 has been hypothesized to play a significant role in synaptic plasticity and in learning and memory. However, functions of CaMK4 in a variety of behaviors, e.g., motor function, nociception, fear, anxiety, depression, learning and so on, have not yet been fully elucidated. To gain more insight into behavioral significance of CaMK4, we subjected CaMK4 -/- mice to a battery of behavioral tests, including neurological screen, light/dark transition, open field, elevated plus maze, social interaction, rotarod, hot plate, prepulse inhibition, Porsolt forced swim, 8-armed radial maze, Barnes maze, fear conditioning, latent inhibition, and passive avoidance tests. CaMK4 -/- mice exhibited increased social interaction in home cage. They did not display any deficit in spatial reference memory and working memory tests, but had mild performance deficit in fear conditioning tests. These results indicated selective and specific involvement of CaMK4 in regulating emotional behaviors. [J Physiol Sci. 2006;56 Suppl:S62]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2006 (0), 062-062, 2006

  一般社団法人　日本生理学会

キーワード

• CaMK4
• behavioral test battery
• fear conditioning
• social interaction

詳細情報

• CRID: 1390282680705668096
• NII論文ID: 130005448211
• DOI: 10.14849/psjproc.2006.0_062_2
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可