行動リズムと細胞リズムのリンク–ショウジョウバエから哺乳動物まで

• 池田 真行

  富山大学大学院理工学研究部

書誌事項

タイトル別名

• Linkage between cellular oscillations and behavioral circadian rhythms from Drosophila to mammals

抄録

Daily temporal patterns from cellular activities to animal behaviors are governed by the endogenous clock system, which has been proposed to be driven by gene transcription-translation feedback loops. The circadian oscillations in the clock genes have been observed in a wide range of systems, from unicellular organisms to mammalian cells and from peripheral organs to the central nervous system. Cytosolic free Ca²⁺ is a general intracellular messenger that regulates diverse cellular processes, including membrane potentials, secretions and gene expressions, and is involved in a generation of various biological rhythms. Our recent studies in neurons playing a critical role for circadian locomotor rhythms in mammals and fruit flies demonstrated Ca²⁺ oscillations with a circadian (c.a. 24 h) period. In mice, hypothalamic suprachiasmatic nucleus (SCN) neurons, which are known as circadian pacemakers, display autonomous clock gene oscillations, cytosolic Ca²⁺ oscillations, action potential firing rhythms, and secretion rhythms in circadian fashion. In fruit flies, a larval circadian clock may be located within peripheral endocrine organs, such as the corpus allatum (CA) and prothoracic gland (PG), where display robust circadian rhythms in nuclear Per protein levels, even in the in vitro cultures up to for a week. In adult flies, the circadian rhythm is more evident in the specific cerebral neurons, the ventral lateral neurons (LNvs) which receive visual inputs from the compound eyes. The recent technical breakthroughs to visualize these cellular rhythms will be discussed in the present presentation. [J Physiol Sci. 2007;57 Suppl:S63]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2007 (0), 063-063, 2007

  一般社団法人　日本生理学会

キーワード

• Circadian clock
• Cytosolic calcium
• Period gene

詳細情報

• CRID: 1390001205728387584
• NII論文ID: 130005448819
• DOI: 10.14849/psjproc.2007.0_063_2
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可