学習記憶情動に関係するオープンフィールド行動と脳内元素間の因果関係

• 瀧田 正寿

  産総研・人間福祉医工学

• 稲垣 和三

  産総研・計測標準

書誌事項

タイトル別名

• Causality between brain chemical element and open-field behaviors concerning learning, memory, and emotion

抄録

We developed a simple learning and memory test on the basis of repetitive counting locomotion activity and rearing for one hour in an open field. Here we tested whether the causal relationship between brain chemical elements and administrated Pb-induced behavioral changes can be detected. Correlation analysis was applied for 4320 pairs; 6 brain areas that are reportedly involved in learning, memory, and emotion (prefrontal cortex, nucleus accumbens, amygdala, dorsal hippocampus, ventral hippocampus, and cerebellum punched or cut out from brain slices) x (15 chemical elements [Mg, Al, P, Ca, Mn, Fe, Co, Ni, Cu, Zn, Rb, Sr, Ag, Ba, and Pb] measured by Inductively Coupled Plasma Mass Spectroscopy) x behavioral data (locomotor activity and rearing). We detected the significance of brain area-specific positive and negative correlations between chemical elements themselves then between chemical elements and the behavioral indexes of our developed method, which seems to be practical and useful for the initial behavioral test of learning and memory regarding developmental neurotoxicology. [J Physiol Sci. 2007;57 Suppl:S166]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2007 (0), 166-166, 2007

  一般社団法人　日本生理学会

キーワード

• locomotor
• rearing
• chemical element
• memory
• emotion

詳細情報

• CRID: 1390282680704986368
• NII論文ID: 130005449114
• DOI: 10.14849/psjproc.2007.0_166_4
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可