Orexin is necessary both for hypercapnic ventilatory responses during wakefulness and for prevention of apneas during sleep

• Nakamura Akira

  Dept. Auto. Physiol, Grad. Sch. Med. Chiba Univ. Chiba, Japan

• Wei Zhang

  Dept. Mol. & Intgr. Physiol., Grad. Sch. Med. Chiba Univ. Chiba, Japan

• Yanagisawa Masashi

  Univ. Texas SW Medical Center

• Fukuda Yasuichiro

  Dept. Auto. Physiol, Grad. Sch. Med. Chiba Univ. Chiba, Japan

• Kuwaki Tomoyuki

  Dept. Auto. Physiol, Grad. Sch. Med. Chiba Univ. Chiba, Japan Dept. Mol. & Intgr. Physiol., Grad. Sch. Med. Chiba Univ. Chiba, Japan

Bibliographic Information

Other Title

• オレキシンは覚醒時高炭酸ガス換気応答及び睡眠時無呼吸抑制のために必要である

Abstract

We examined whether intrinsic orexin participates in the control of breathing in a vigilance state-dependent manner. Ventilation was recorded together with electroencephalography and electromyography for 6 hrs during the daytime in prepro-orexin knockout mice (ORX-KO) and wild-type (WT) littermates. Respiratory parameters were separately determined during quiet wakefulness (QW), slow wave sleep (SWS), or rapid eye movement (REM) sleep. Basal ventilation was normal in ORX-KO, irrespective of vigilance states. Hypercapnic ventilatory response during QW in ORX-KO was significantly smaller than that in WT mice, whereas the responses during SWS and REM in ORX-KO were comparable to those in WT mice. Hypoxic responses during wake and sleep periods were not different between the genotypes. Spontaneous but not post-sigh sleep apneas were more frequent in ORX-KO than in WT littermates during both SWS and REM sleep. We concluded that orexin plays a crucial role both in CO2-sensitivity during wakefulness and in preservation of ventilation stability during sleep. [J Physiol Sci. 2007;57 Suppl:S214]

Journal

• Proceedings of Annual Meeting of the Physiological Society of Japan

  Proceedings of Annual Meeting of the Physiological Society of Japan 2007 (0), 214-214, 2007

  PHYSIOLOGICAL SOCIETY OF JAPAN

Keywords

• chemoreception
• sleep
• apnea
• orexin

Details

• CRID: 1390282680705489280
• NII Article ID: 130005449167
• DOI: 10.14849/psjproc.2007.0_214_2
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed