Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure

• Yamazaki Toshiya

  Dep. of Phys. Wakayama Med. Univ. Wakayama, Japan Kansai college of oriental medicine, Osaka, Japan

• Cui He

  Dep. of Phys. Wakayama Med. Univ. Wakayama, Japan

• Nakamura Ken

  Dep. of Phys. Wakayama Med. Univ. Wakayama, Japan

• Kouda Ken

  Dep. of Phys. Wakayama Med. Univ. Wakayama, Japan

• Hatada Atsutoshi

  Dep. of Phys. Wakayama Med. Univ. Wakayama, Japan

• Tsubota Yuji

  Osaka Kawasaki Rehabilitation Univ, Osaka, Japan

• Yukawa Kazunori

  Dep. of Phys. Wakayama Med. Univ. Wakayama, Japan

• Maeda Masanobu

  Dep. of Phys. Wakayama Med. Univ. Wakayama, Japan

Bibliographic Information

Other Title

• ウロコルチンの延髄孤束核への直接導入は血圧を降下させる

Abstract

Urocortin (Ucn), a member of the corticotrophin-releasing factor (CRF) peptide family, has appetite-suppressing and cardiovascular effects. Its intravenous or subcutaneous injection of Ucn reportedly decreased the mean arterial blood pressure (MABP) and increased the heart rate (HR). We report that at 50 and 75 pmol/50 nl, Ucn, suspended in artificial cerebrospinal fluid (ACSF) and microinjected into the rat nucleus tractus solitarii (NTS), produced a significant, dose-dependent reduction in both MABP and HR. Our results suggest that Ucn may act as a neurotransmitter or neuromodulative substance in the NTS and that it may play a role in cardiovascular regulation in vivo. [J Physiol Sci. 2007;57 Suppl:S211]

Journal

• Proceedings of Annual Meeting of the Physiological Society of Japan

  Proceedings of Annual Meeting of the Physiological Society of Japan 2007 (0), 211-211, 2007

  PHYSIOLOGICAL SOCIETY OF JAPAN

Keywords

• urocortin
• nucleus tractus solitarii(NTS)
• cardiovascular effects
• central control mechanisms of circulation
• medulla oblongata

Details

• CRID: 1390001205727912448
• NII Article ID: 130005449201
• DOI: 10.14849/psjproc.2007.0_211_3
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed