神経活動, 脳循環の反応とベースラインの活動: ラットにおける高炭酸ガス負荷の研究

DOI
  • 根本 正史
    東京都精神医学総合研究所・脳機能解析研究チーム
  • 星 詳子
    東京都精神医学総合研究所・脳機能解析研究チーム
  • 佐藤 知絵
    東京都精神医学総合研究所・脳機能解析研究チーム
  • 井口 義信
    東京都精神医学総合研究所・脳機能解析研究チーム
  • 黄 敬華
    東京都精神医学総合研究所・脳機能解析研究チーム

書誌事項

タイトル別名
  • Neural and hemodynamic responses and their baseline activities: a study of hypercapnic challenge in rats

抄録

To investigate the effect of hypercapnia on the neural and hemodynamic responses, we measured broad band electrophysiological signals (local field potentials, LFP < 100 Hz; multiunit activity, MUA > 300 Hz), optical intrinsic signals (586 and 605 nm, indicators of CBV and oxygenation), spectral changes in reflected light (400-900 nm) and laser-Doppler blood flow. Rats were anesthetized with alpha-chloralose and artificially ventilated with muscle relaxants. Hypercapnic challenge was performed by 5% and 10% CO2 inhalation. We recorded these signals while delivering 2-s electrical pulses to the hindpaw. We observed decreases in both neural (LFP, MUA) and hemodynamic (CBF, CBV) responses, and prolonged deoxyhemoglobin increases in the early phase with attenuation of deoxyhemoglobin decreases in the late phase (i.e., disruption of hyperoxygenation responses), compared with those responses during normocapnia. These results suggested that imaging of early dip optical intrinsic signals and positive BOLD fMRI signals might not accurately reflect neural responses in strength and space domains during hypercapnia. [J Physiol Sci. 2007;57 Suppl:S245]

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詳細情報 詳細情報について

  • CRID
    1390001205729145600
  • NII論文ID
    130005449255
  • DOI
    10.14849/psjproc.2007.0_245_3
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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