Pathogenesis on deep vein thrombosis

• Ueshima Shigeru

  Dept. of Food Sci. and Nutri. Kinki Univ. Sch. of Agri., Nara, Japan Dept. of Physiol. Kinki Univ. Sch. of Med., Osakasayama, Japan

• Matsuo Osamu

  Dept. of Physiol. Kinki Univ. Sch. of Med., Osakasayama, Japan

Bibliographic Information

Other Title

• 深部静脈血栓症の病態

Abstract

Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE). It was recently reported that the mortality rate from PTE markedly increased for the last 5 decades. Furthermore, it was demonstrated that the incidence of DVT in Japan was almost same as that in western country in patients with total hip replacement or total knee replacement surgery. Dr. Virchow reported a century ago that three general changes caused thrombosis; changes in the vessel wall, changes in the blood flow and changes in the blood composition. These changes are called as Virchow's triad. An abnormality in Virchow's triad is involved in the pathophysiology of DVT. The stasis, changes in endothelial function and/or activation of pro-coagulant activity induce venous thrombosis. Unlike an artery, vein has venous valves. Venous valves guide the direction of blood flow and prevent regurgitation, and subsequently return blood to heart from peripheral region against gravity. Venous thrombosis in the lower limbs typically occurred in the valve pockets. At the valve pockets, decreased shear stress and increased hypoxia are observed and they induce venous thrombosis. The venous thrombus generated from the valve pocket does not attach to the vessel wall and this venous thrombus is released. Then the thrombus reaches to pulmonary artery, and pulmonary embolism is subsequently occurred. Sudden death after long flight, certain surgical operation or long bed-rest may be due to this pulmonary embolism. Therefore, the prevention of DVT is important. [J Physiol Sci. 2008;58 Suppl:S39]

Journal

• Proceedings of Annual Meeting of the Physiological Society of Japan

  Proceedings of Annual Meeting of the Physiological Society of Japan 2008 (0), 039-039, 2008

  PHYSIOLOGICAL SOCIETY OF JAPAN

Keywords

• vein
• thrombosis
• DVT
• PE

Details

• CRID: 1390282680705346432
• NII Article ID: 130005449381
• DOI: 10.14849/psjproc.2008.0_039_3
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed