ホルマリン誘発侵害刺激に対する雌性ラット分界条床核のCREBの役割

• 萩原 裕子

  Dept. Physiology., Yokohama City Univ. Sch. Med., Yokohama, Japan

• 舩橋 利也

  Dept. Physiology., Yokohama City Univ. Sch. Med., Yokohama, Japan

• 有田 順

  Department of Physiology, Graduate School of Medicine, University of Yamanashi, Japan

• 貴邑 冨久子

  Dept. Physiology., Yokohama City Univ. Sch. Med., Yokohama, Japan international university of health and welfare, School of Nursing and Rehabilitation Sciences at Odawara, Japan

• 高橋 琢哉

  Dept. Physiology., Yokohama City Univ. Sch. Med., Yokohama, Japan

書誌事項

タイトル別名

• Role of CREB in the response of the bed nucleus of the stria terminalis (BST) to formalin-induced nociceptive stimuli in female rats

抄録

Sex differences in the response to nociceptive stimuli have long been recognized in many species. For example, in rats, females are more sensitive to formalin-induced nociceptive stimuli than males, as revealed by behavioral test. However, the neural mechanism for sex differences in the response to nociceptive stimuli was still unclear. In the previous study, we showed that females were more sensitive to formalin-induced nociceptive stimuli than males, as revealed by behavioral test. We looked for a possible sex difference in the response of the brain to formalin-induced nociceptive stimuli by checking the expression of phosphorylated cAMP response element-binding protein (pCREB) as a marker of neural activity. We found that, in the bed nucleus of the stria terminalis lateral subdivision (BSTL), the number of cells expressing pCREB was increased 5-10 min after formalin injection in female rats but not in male rats. In the present study, we examined the function of CREB in the BSTL. We found that the expression of a dominant negative form of CREB (mCREB) using adenovirus vector, significantly attenuated the response to formalin only in females but not in males, suggesting that CREB in the BSTL play a role for controlling pain-related behavior only in females. [J Physiol Sci. 2008;58 Suppl:S165]

収録刊行物

• 日本生理学会大会発表要旨集

  日本生理学会大会発表要旨集 2008 (0), 165-165, 2008

  一般社団法人　日本生理学会

キーワード

• formalin test
• CREB
• sex difference
• adenovirus
• BST

詳細情報

• CRID: 1390282680705115392
• NII論文ID: 130005449668
• DOI: 10.14849/psjproc.2008.0_165_3
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可