Role of CREB in the response of the bed nucleus of the stria terminalis (BST) to formalin-induced nociceptive stimuli in female rats
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- Hagiwara Hiroko
- Dept. Physiology., Yokohama City Univ. Sch. Med., Yokohama, Japan
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- Funabashi Toshiya
- Dept. Physiology., Yokohama City Univ. Sch. Med., Yokohama, Japan
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- Arita Jun
- Department of Physiology, Graduate School of Medicine, University of Yamanashi, Japan
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- Kumura Fukuko
- Dept. Physiology., Yokohama City Univ. Sch. Med., Yokohama, Japan international university of health and welfare, School of Nursing and Rehabilitation Sciences at Odawara, Japan
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- Takahashi Takuya
- Dept. Physiology., Yokohama City Univ. Sch. Med., Yokohama, Japan
Bibliographic Information
- Other Title
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- ホルマリン誘発侵害刺激に対する雌性ラット分界条床核のCREBの役割
Abstract
Sex differences in the response to nociceptive stimuli have long been recognized in many species. For example, in rats, females are more sensitive to formalin-induced nociceptive stimuli than males, as revealed by behavioral test. However, the neural mechanism for sex differences in the response to nociceptive stimuli was still unclear. In the previous study, we showed that females were more sensitive to formalin-induced nociceptive stimuli than males, as revealed by behavioral test. We looked for a possible sex difference in the response of the brain to formalin-induced nociceptive stimuli by checking the expression of phosphorylated cAMP response element-binding protein (pCREB) as a marker of neural activity. We found that, in the bed nucleus of the stria terminalis lateral subdivision (BSTL), the number of cells expressing pCREB was increased 5-10 min after formalin injection in female rats but not in male rats. In the present study, we examined the function of CREB in the BSTL. We found that the expression of a dominant negative form of CREB (mCREB) using adenovirus vector, significantly attenuated the response to formalin only in females but not in males, suggesting that CREB in the BSTL play a role for controlling pain-related behavior only in females. [J Physiol Sci. 2008;58 Suppl:S165]
Journal
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- Proceedings of Annual Meeting of the Physiological Society of Japan
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Proceedings of Annual Meeting of the Physiological Society of Japan 2008 (0), 165-165, 2008
PHYSIOLOGICAL SOCIETY OF JAPAN
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Keywords
Details 詳細情報について
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- CRID
- 1390282680705115392
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- NII Article ID
- 130005449668
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed