Management of Pulmonary Mucormycosis Based on a Polymerase Chain Reaction (PCR) Diagnosis in Patients with Hematologic Malignancies: A Report of Four Cases
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- Ino Kazuko
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Nakase Kazunori
- Department of Hematology and Oncology, Mie University Hospital, Japan Cancer Center, Mie University Hospital, Japan
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- Nakamura Akiko
- Central Clinical Laboratories, Mie University Hospital, Japan
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- Nakamori Yoshiki
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Sugawara Yumiko
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Miyazaki Kana
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Monma Fumihiko
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Fujieda Atsushi
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Sugimoto Yuka
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Ohishi Kohshi
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Masuya Masahiro
- Department of Hematology and Oncology, Mie University Hospital, Japan
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- Katayama Naoyuki
- Department of Hematology and Oncology, Mie University Hospital, Japan
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Abstract
<p>Pulmonary mucormycosis (PM) is a life-threatening fungal infection in patients with hematologic malignancies, and early and accurate diagnostic modalities are urgently needed. We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hematologic malignancies who were strongly suspected of having PM. In these four patients, the Rhizopus species was identified in two patients, and the Cunninghamella and Absidia species in one each. Based on these molecular findings, all of the patients were successfully treated via targeted therapy with liposomal amphotericin B. In this report, a PCR analysis proved very useful for managing PM in patients with hematologic malignancies. </p>
Journal
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- Internal Medicine
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Internal Medicine 56 (6), 707-711, 2017
The Japanese Society of Internal Medicine
