2.膵癌早期発見に向けた家族性膵癌登録  [in Japanese] Japanese Familial Pancreatic Cancer Registry with the aim to early detection of pancreatic cancer  [in Japanese]

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Abstract

<p>家族性膵癌家系の定義は「膵癌に罹患した一対(2名)以上の第一度近親者がいる家系」であり,家族性膵癌家系に属する個人は膵癌の発症リスクが高いことが報告されている.米国Johns Hopkins大学で1994年に家族性膵癌登録制度(NFPTR)が発足し各分野で研究実績を残している.日本でも2014年に家族性膵癌登録制度(JFPCR)が発足,登録が進んでいる.JFPCRを基盤として膵癌の早期発見,発癌の原因遺伝子の検索,治療法開発など,様々な研究開発が期待されるが,中でも膵癌の早期発見は医療ニーズが高い.膵癌発症の高リスク群である家族性膵癌家系が登録,フォローアップされていくJFPCRは膵癌の早期発見を目指した研究開発を行うのに適したプラットフォームといえ,今後の研究開発が期待されている.</p>

<p>Familial pancreatic cancer (FPC) is defined as kindred in whom at least a pair of first-degree relatives have been diagnosed with pancreatic cancer. Members of FPC kindred have an increased risk of developing pancreatic cancer. The National Familial Pancreas Tumors Registry (NFPTR) at Johns Hopkins Hospital is the first and largest registry in the world and was established in 1994, and this project has produced robust results. The Japan Pancreas Society established the Japanese Familial Pancreatic Cancer Registry (JFPCR) in 2014. This project is expected to identify causative cancer genes, and improve new strategies for the screening and treatment of Japanese pancreatic cancer patients. Especially, the improved screening for pancreatic cancer is a most desirable objective. The JFPCR provides a system of periodic follow up of individuals that are at high risk of developing pancreatic cancer and serves as valuable platform for developing and testing new interventions for the screening and early detection of pancreatic cancer.</p>

Journal

  • Suizo

    Suizo 32(1), 23-29, 2017

    Japan Pancreas Society

Codes

  • NII Article ID (NAID)
    130005450419
  • Text Lang
    JPN
  • ISSN
    0913-0071
  • Data Source
    J-STAGE 
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